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Related to proenzymes: Enzyme precursors


The inactive or nearly inactive precursor of an enzyme, converted into an active enzyme by proteolysis. Also called zymogen.


(Biochemistry) the inactive form of an enzyme; zymogen


(ˈzaɪ mə dʒən, -ˌdʒɛn)

any of various enzyme precursor molecules that may change into an enzyme as a result of catalytic change. Also called proenzyme.
[< German (1875); see zymo-, -gen]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.proenzyme - any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
organic compound - any compound of carbon and another element or a radical
References in periodicals archive ?
Proenzymes characteristically existing as inactive in the intravascular space along with cofactors, cations, and cell-associated phospholipids comprise the coagulation system.
Many of the MMPs are specifically regulated at the level of gene expression, but their production as inactive proenzymes is another important level of functional regulation [6].
MMPs are produced in their latent form, as proenzymes (inactive zymogens) or pro-MMPs and, thus, require a process of proteolytic activation [21].
Matrix-metalloproteinases (MMPs) are synthesized as proenzymes and typically activated by proteolytic removal of a propeptide (22).
Calpains, a family of Ca [sup]2+ -dependent cysteine proteases, exist as inactive proenzymes under physiological conditions.
The acinar cells of the pancreas produce and transport a variety of chemical compounds called proenzymes which are stored in zymogen granules that exit the body via the digestive system where the proenzymes are converted into active enzymes and assist in the digestion of fats, proteins, and carbohydrates.