The oestrogen and progestational
hormones may sensitize the dopamine receptors previously at stria nigra level and induce chorea in individuals who are vulnerable to this complication by virtue of pre-existing pathology in basal ganglia.
There is a boxed warning in the ospemifene label that says, "in the uterus, ospemifene has estrogenic agonistic effects." (1) Despite the fact that ospemifene is not an estrogen (it's a SERM), it goes on to state, "there is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogen." This statement actually caused The Medical Letter to initially suggest that patients receiving ospemifene also should receive a progestational
agent (something they later retracted).
Short-term effects of a progestational
contraceptive drug on food intake, resting energy expenditure, and body weight in young women.
It set into motion a string of studies on the use of 17-OHPC and other progestational
compounds in women with a variety of conditions associated with an increased risk for preterm birth.
Balogh Jr, "Progesterone catabolism in the rat ovary: a regulatory mechanism for progestational
potency during pregnancy," Endocrinology, vol.
The characteristics of the vaginal epithelium change depending on variations in the concentration of estrogenic and progestational
In the year in question, the editorial Progestational
compounds by Vespasiano Ramos broke the silence: the author emphasizes the therapeutic potential of sex hormones for a range of gynaecological problems (bleeding, menstrual regularization) and writes that "the field of application of these substances is huge, therefore, with, today, the emphasis being placed above all on their use in birth control." The pills are presented in positive form.
Given that after 24 weeks, there was no change in serum estradiol levels and vaginal or endometrial atrophy, this implies no need to oppose the estrogen with a progestational
agent, although 24 weeks is certainly not the same as long-term use.
An exaggerated response of uterine mucosa to chronic progestational
stimulation during luteal phase caused by altered estrogenprogesterone receptors leads to cystic endometrial hyperplasia with excess secretions in uterine lumen (Fayrer-Hoskens et al., 1992) and secondary bacterial invasion particularly of E.
Intravascular thrombosis can result from hematological disturbances as in protein S deficiency and high progestational
states in females15.
Mechanism of action of bolandiol (19-nortestosterone-3beta,17betadiol), a unique anabolic steroid with androgenic, estrogenic, and progestational