However, not many know that vitamin D is not really a vitamin but a prohormone
that our bodies actually produce from cholesterol.
Vitamin D is a prohormone
that plays an effective role in glucose metabolism; cardiovascular, immunologic, and dopaminergic system functions, in addition to muscle-skeletal system functions (9).
In the previously reported main outcome, 8 weeks after discharge the sacubitril/valsartan group had a 29% greater reduction in NT-proBNP (the N-terminal prohormone
of brain natriuretic peptide) and a 42% lower rate of the composite clinical endpoint of cardiovascular death or heart failure rehospitalization than the enalapril group (N Engl J Med.
Vitamin D is a lipid-soluble prohormone
produced in the human skin exposure to ultraviolet radiation.
PCT is a 14.5kDa prohormone
encoded by the CALC-1 gene, belonging to the calcitonin super-family of peptides.
and proneuropeptide synthesis and secretion.
Because DHEA is a prohormone
, it is converted to estrogen and androgen in the vagina.
Furthermore, after adjustment was made for subject age, gender, prohormone
brain natriuretic peptide levels, and ejection fraction at recruitment, there was a 76 percent relative risk reduction in heart failure with the intensified strategy versus conventional treatment.
No significant between-treatment phase differences were observed in daily activity levels (5,497 versus 5,503 accelerometry units; P = 0.91), Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (62.6 versus 61.9; P = 0.39), functional class (2.5 versus 2.5; P = 0.43), echocardiographic E/e' ratio (16.4 versus 16.6; P = 0.93), or N-terminal fragment of the prohormone
brain natriuretic peptide levels (520 versus 533 pg/mL; P = 0.74).
Results: Baseline sST2 levels were positively correlated with heart rate (r = 0.327, P = 0.002), Killip class (r = 0.408, P = 0.000), lg N-terminal prohormone
B-type natriuretic peptide (r = 0.467, P = 0.000), lg troponin I (r = 0.331, P = 0.000), and lg C-reactive protein (r = 0.307, P = 0.000) and negatively correlated to systolic blood pressure (r = −0.243, P = 0.009) and LV ejection fraction (r = −0.402, P = 0.000).
The major secretory product of the thyroid is a prohormone
(T4), which is activated in peripheral tissues by outer ring deiodination to T3.
Second, in the urogenital sinus and urogenital tubercle, it acts as a prohormone
for DHT, the third hormone of male virilization.