The hyalinotic lesions are usually formed by nonspecific trapping of the high-molecular-weight circulating proteins, such as IgM and C1q, and these lesions must be distinguished from the immune-complex deposits seen in other forms of glomerular diseases, where additional components of the complement, that is, C3 and properdin
, also display reactivity in these deposits.
Kompleman sisteminin gec komponentlerinden olan C5-C9 eksikliginde meningokoklar ile rekurren menenjit gelisimi bilinirken, properdin
eksikliginde meningokokkal menenjitler daha yuksek mortalite ile seyretmektedir.
They discuss such topics as B cell signaling and fate decision; immune function control; the molecular components, geometry, and timing of T cell activation and synapse formation; the influence of bacterial carbohydrates on the adaptive immune system; new findings on properdin
and the role in inflammatory and autoimmune diseases; allergy vaccines based on allergen structures; adaptive immune regulation in the gastrointestinal tract; the acute inflammatory response and sterile stimuli; the role of antibodies in HIV vaccines; and functions of notch signaling in the immune system.
This study indicates that a combined deficiency of both properdin
and MBL increases the risk of infection with N.
Fearon DT, Ruddy S, Schur PH, et al: Activation of the properdin
pathway of complement in patients with gram negative bacteremia.
Gliatech is developing therapeutic antibodies to properdin
as potential treatments for acute inflammatory conditions which result from cardiopulmonary bypass surgery, heart attacks and stroke.
Acquiring rights from Gliatech to antibodies against the complement protein properdin
Terminal kompleman sistem [C3 eksikligi, C5-C9] eksikligi, properdin
eksikligi, anatomik veya fonksiyonel aspleni olan kisiler invaziv meningokok hastaligi gorulme riski yuksek gruplardir.
Gliatech presently owns certain patents related to the complement protein, properdin