Pulmonary edema complicating
prostacyclin therapy in pulmonary hypertension associated with scleroderma: A case of pulmonary capillary hemangiomatosis.
1981) Spectral evidence for the cytochrome P450 nature of
prostacyclin synthetase.
The global scleroderma diagnostics and therapeutics market segmentation is based on indication (localized, systemic), test type (blood tests, electrocardiogram and echocardiogram, imaging techniques, pulmonary function tests, skin biopsy), drug class (calcium channel blockers, chelating agents, corticosteroids, endothelin receptor agonists, immunosuppressive agents, PDE-5 inhibitors,
prostacyclin analogues, ACE inhibitors, H2 blockers, proton pump inhibitors).
Many promising newer therapies like
prostacyclin analogue, endothelin receptor antagonist, phosphodiesterase inhibitors improve clinical function and haemodynamic measures.
James, Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of
prostacyclin synthesis by COX-2, The Journal of Immunology, 167(5), 2831-2838 (2001).
Effect of curcumin on platelet aggregation and vascular
prostacyclin synthesis.
Estrogen a receptors are mainly present on vessels endothelial cells therefore when there are less a receptors there may be less NO and
prostacyclin produced that may increase risks of thromboembolism in premenopausal women.
Prostanoids are drugs that mimic
prostacyclin, a strong endogenous vasodilator (Tartavoulle, 2011).
13) For patients unwilling to undergo pregnancy termination, there are data showing successful use of PAH-specific medications like sildenafil, and
prostacyclin analogues.
These include the discovery of the vasodilator
prostacyclin, that of endothelium-derived relaxing factor and its identification as nitric oxide (NO).
Prostacyclin synthase is the enzyme responsible for the production of the eicosanoid vasodilator
prostacyclin (PGI2).
5) In the CV system,
prostacyclin is synthesized by COX-2.
