13] found
proteoglycan aggregates concentration to decrease as age increased.
They were then processed according to routine procedures and the slides were stained with hematoxylin and eosin (H&E) and Safranin O fast green to evaluate the concentration of
proteoglycans.
It is covalently attached on several core proteins creating a variety of
proteoglycans (PGs) found in the extracellular matrix (ECM) and cell membrane, but also intracellularly (Elgawish et al.
Purpose: Glycosaminoglycans (GAGs) and
proteoglycans (PG) in addition to collagen are the main components of extracellular matrix (ECM).
The observed high concentration of the discussed biomarker, which is strongly related to CS concentration, seems to indicate a significant increase in anabolic processes of aggrecan, but not big enough to balance the degree of the
proteoglycan degradation.
In this context, we expected that the systemic administration of
proteoglycan (PG) that is a cartilage compound would induce antigenspecific tolerance and therefore restrain arthritis development.
Proteoglycan degradation by the ADAMTS family of proteinases.
SJS types IA and IB derive from mutations of the same gene, the HSPG2 gene, which codes for perlecan, a heparin sulfate
proteoglycan.
Immediately after a central nervous system injury, molecules known as
proteoglycans collect in scar tissue at the injury site and in the perineuronal net.
Given the biology of IVD degeneration, it is difficult to imagine that any externally applied therapy could heal/regenerate or 'rehydrate' the IVD that does not provide cellular replacement, regeneration of the
proteoglycan networks and/or the VEPs.
Another study examined the prognostic significance of versican, the
proteoglycan linking HA, collagen I, fibronectin, and laminin within the ECM [93].
Subsequently, 5-[micro]m-thick sections from the mid-sagittal plane of the PPT complex were stained with Safranin O to examine the BTJ
proteoglycan profile and with hematoxylin & eosin (H&E) to examine the general morphology; the latter analysis included an assessment of the tendon collagen fibers under a polarized microscope (Nikon Eclipse 50i, Nikon Inc.
