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Noun1.proteosome - a form of vaccine that can be administered by an inhaler
vaccine, vaccinum - immunogen consisting of a suspension of weakened or dead pathogenic cells injected in order to stimulate the production of antibodies
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Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma.
NAC maybe able to maintain the activity of Na+/K+ pump in muscle due to a redox-dependent [64, 65] attenuation of sarcoplasmic reticulum injury [11] that results in a lower calcium release and thus a reduced activity of muscle's proteolytic proteins such as the proteosome and calpains [66, 67].
40 fold), in addition to its role in protein degradation as a component of the proteosome, is known to mediate the LPS-induced activation of macrophages with consequent transcription of genes that encode proinflammatory regulators of the immune response (Martinez-Solano et al.
TRIM32 is ubiquitously expressed and encodes a protein with E3 ubiquitin ligase activity [sup][58] responsible for attaching ubiquitin molecules to lysine residues of target proteins prior to proteosome degradation.
It is regulated by increased synthesis at low Iron concentration and increased degradation by proteosome at high iron concentration.
Considering this apparent relationship between FoxO1 and skeletal muscle size and the influence of the Akt and mTOR-mediated signaling on increasing protein synthesis efficiency and/or capacity (9, 17,23,24) and regulation of genes known to boost protein ubiquination and proteosome mediated degradation (16,31,32), our work has focused on investigating the impact of FoxO1 overexpression on the activity of the major components within this complex signaling pathway.
Influenza Live recombinant vaccine viral vectors for the delivery of influenza antigens, proteosome vaccines and DNA-based vaccines.
A possible mechanism is IRS phosphorylation in the serine and threonine amino acids and not in tyrosine; this phosphorylation may induce the dissociation of IRSs from IR, hinder or diminish IR phosphorylation in tyrosine, or induce the degradation of IRS by the proteosome (21-23).
Studies using proteosome inhibitor MG132 suggested that omega-3 PUFAs induce degradation of the PcG protein EZH2 through posttranslational mechanisms.
Proteosome, in turn, is a large protein enzyme that breaks down oxidized proteins that would otherwise accumulate and cause cells to die.