prothrombin


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pro·throm·bin

 (prō-thrŏm′bĭn)
n.
A plasma protein that is converted into thrombin during blood clotting.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

prothrombin

(prəʊˈθrɒmbɪn)
n
(Biochemistry) biochem a zymogen found in blood that gives rise to thrombin on activation. See also phylloquinone
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

pro•throm•bin

(proʊˈθrɒm bɪn)

n.
a plasma protein involved in blood coagulation that is converted to thrombin.
[1895–1900]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.prothrombin - a protein in blood plasma that is the inactive precursor of thrombin
clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

pro·throm·bin

n. protrombina, una de las cuatro proteínas principales del plasma junto a la albúmina, la globulina y el fibrinógeno.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
The negative association between Prothrombin G20210A polymorphism and the risk of RVO was mainly detected in Caucasian populations.
Thrombocyte count, clotting time, prothrombin time (PT), thrombin time (TT), active partial thromboplastin time (aPTT) and buccal mucosa bleeding time (BMBT) are the most frequently used parameters in determining coagulation disorders (Forsythe and Willis, 1989; ogurtan et al., 2002; Smith et al., 2005).
This review highlighted the pharmacological characteristics of various reversal agents including Prothrombin complex concentrate, Activated Prothrombin complex concentrate, Recombinant factor VIIa, Andexanet alfa, and Ciraparantag used in the treatment of laboratory parameters prothrombin time (PT) and clotting time (CT) for the reversal of rivaroxaban.
[USPRwire, Wed Oct 24 2018] Prothrombin complex concentrate is a combination of blood clotting factors used to treat and prevent bleeding in patients having factor IX deficiency.
Current guidelines recommend the use of 4-factor prothrombin complex concentrate (4F-PCC) over fresh frozen plasma for the emergent correction of coagulopathy in patients with vitamin K antagonist (VKA)-associated major bleeding.
Objective: To determine the frequency of prothrombin gene mutation in venous thromboembolism in our population.
Serum des-gamma-carboxy prothrombin (DCP), also known as prothrombin-induced by vitamin K absence-II (PIVKA-II), was first reported by Liebman et al.
However, the patient was found to have a heterozygous prothrombin G20210A (factor II) mutation.
Ganzert et al [4] retrospectively analysed the outcome of a large series of amatoxin intoxication cases and found that predictors of death were the prothrombin time in combination with the serum creatinine level on 3-10 days after ingestion.
It is known that mutations in the prothrombin gene are a risk factor for thrombosis.
Research variables were AST/ALT ratio, prothrombin time, platelet conunt, serum albumin and serum bilirubin.
Her thrombophilia work-up was positive for a prothrombin G20210A gene mutation in heterozygous form.