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Related to proto-oncogene: tumor suppressor gene


 (prō′tō-ŏn′kə-jēn′, -ŏng′kə-)
A normal gene that has the potential to become an oncogene.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.proto-oncogene - a normal gene that has the potential to become an oncogene
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
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References in periodicals archive ?
In the COSMIC database for the KRAS and NRAS proto-oncogene receptor tyrosine kinase proteins activating Raf/MEK/ERK and PI3 kinase pathways, mutation rates in seminoma cases are 9% and 5%, respectively, while there are no mutations in nonseminoma cases.
High prevalence of activating ret proto-oncogene rearrangements in thyroid tumors from patients who had received external radiation.
ROS-1 is a proto-oncogene that is located on chromosome 6 that encodes the transmembrane tyrosine kinase receptors of the insulin receptor family.
Altered lymphoid development in mice deficient for the mAF4 proto-oncogene. Blood 2000; 96: 705-710.
Eng, "Seminars in medicine of the Beth Israel Hospital, Boston: The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung's disease," The New England Journal of Medicine, vol.
The C-kit proto-oncogene protein (a transmembrane receptor Type-III tyrosine kinase) on binding to its ligand, stem cell factor begins a signal cascade that contributes to the growth and differentiation of multiple hematopoietic lineages.
The proto-oncogene BCL-6 in normal and malignant B cell development.
Activating mutations in the RAS proto-oncogene pathway have been detected in 20% of thyroid adenomas with frequencies similar to those found in follicular thyroid (FTC) and papillary thyroid carcinomas (PTC) (11).
BamHI-A rightward open reading frame 1 (BARF1) and BamHI-H rightward open reading frame 1 (BHRF1) are two EBV early gene-encoding proteins homologous to human proto-oncogene c-fms and antiapoptotic gene Bcl-2, respectively.
Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas.
He had a history of B-Raf proto-oncogene, serine/threonine kinase (BRAF)-positive metastatic melanoma with unknown primary and metastasis to the inguinal fossa and right thigh diagnosed two years previously.