Administration of VY-AADC with the posterior trajectory resulted in a mean coverage of the putamen
of 54% and reduced the infusion time by approximately two hours compared to PD-1101.
CSF examination showed normal study and MRI brain revealed bilateral hemorrhagic necrosis of putamen
and posterior limb of right internal capsule with edema in the deep white matter.
The focus of the fMRI analysis was on brain regions implicated in reward and reward valuation, including the orbitofrontal cortex, dorsolateral prefrontal cortex, striatum (caudate, nucleus accumbens, putamen
), insula, midbrain, and amygdala, as these regions are activated by desire and rewarding experience, such as consuming high-sugar food.
Severe HIE may show hyperintense signal in the thalamus and putamen
(with relative sparing of the anterior putamen
However, excess weight was associated with shrinkage in specific regions of the brain: the pallidum, nucleus accumbens, putamen
(linked only to a higher BMI) and caudate (linked only to a higher waist-to-hip ratio).
2 A - C) showed diffuse high T1 signal intensity of the right basal ganglia, with involvement of the caudate nucleus and the putamen
. The diffusion weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping showed no evidence of hypoxic/ ischaemic injury.
MRI showed abnormal cavities in right putamen
, left Nacb, internal capsule and AC of both hemispheres.
They found that viewing a hated person increased the activity in several brain regions, including the medial frontal gyrus, right putamen
, premotor cortex, frontal pole, and medial insula bilaterally.
Among the brain-structure measurements, we focused on basal ganglia volumes (including caudate, putamen
, and globus pallidum), based on previous findings in the BREATHE sample (Mortamais et al.
An admixture of lesions of thalamus, putamen
and peri-Rolandic area is seen in magnetic resonance imaging as a type of lesion due to HIE.