Aloke Dutta, We have developed an innovative triple reuptake inhibitor, D-578, based on a unique pyran
molecular scaffold to address the current therapeutic needs for PTSD and other neurological disorders.
Flavonoids are phenolic compounds that differ in their chemical structure, have 15 carbon atoms in the C6-C3-C6 form, based on the nucleus of two benzene rings, A and B, attached to a pyran
ring, C (Figure 1).
series," compound 36 demonstrated the most interesting inhibitory effect showing 15 [micro]M MIC value; derivative 35 was able to interfere with the NF-[kappa]B/DNA interaction at 35 [micro]M MIC.
Based on the saturation level and opening of the central pyran
ring, flavonoids can be classified into distinct subclasses including flavanols, flavanones, flavanonols, flavonols, anthocyanidins, isoflavones, and flavones [14-16].
To facilitate this [pi]-[pi] stacking interaction, compound 6 in MAO-B stays farther away from FAD than that in MAO-A (Figures 7(e) and 7(f)).The sulfhydryl hydrogen of residue C172 in MAO-B complex also interacts with pyran
and ketone oxygens of 6, which was correspondingly replaced by residue N181 in complex MAO-A (white-circled in Figures 7(c) and 7(d), resp.).
These compounds possess strong antibacterial activity and have a distinctive structure composed of a benzene, a quinone, and a stereospecific pyran
ring (Lu et al.
In addition to lapachol (2, Figure 1), different structural types of naphthoquinones, such as pyran
and furanonaphthoquinones, are found in Bignoniaceae [18, 19] and disclose abroad spectrum of biological activities, including antitumor [20-23], trypanocidal , anti-inflammatory , antifungal , and antiparasitic activities [26-33].
A total of 16 volatile compounds with known antimicrobial and antioxidant properties, such as alcohol, ketone, aliphatic acid, benzene compound, hydrocarbon, furan, and pyran
derivatives, have been identified, and the best antibacterial activity has been demonstrated by the fraction GCF3 (5 mg/ml) .
Carbonara et al., "Novel pyran
based dyes for application in dye sensitized solar cells," Dyes and Pigments, vol.
One is the ring-opening reaction of the depolymerized xylan unit through the cleavage of the hemiacetal bond (between oxygen and C-1 on the pyran
ring), followed by dehydration between the hydroxyl groups on the C2 and C5 positions.
The reaction mixture was subjected to the reaction with [BF.sub.3] in C[H.sub.2][Cl.sub.2] for intramolecular closure of the pyran
In addition, chromone (a derivative of benzopyran with a substituted keto group on the pyran
ring), dinorxanthane sesquiterpene, and other substances isolated from T.