In addition, NN-(2-Acetamidooethyl) hydrozinecarboximidamide hydrochloride (ALT-946), 3-enzyloxycarbonylmethyl-4-methyl-thiazol-3-ium bromide (C36), Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) and pyridoxamine
are other substances that have been shown to reduce or prevent the harmful effects on the kidneys and cardiovascular system through AGE inhibition in experimental animals in different studies (35-39).
Especially, aminoguanidine (Pimagedine) and pyridoxamine
(Pyridorin) prevent diabetic nephropathy by inhibiting albuminuria, glomerular hypertrophy, and mesangial expansion in patients with type 1 diabetes (Bolton et al.
B group vitamins thiamine (Bl); riboflavin (B2); niacin (B3); pantothenic acid (B5); pyridoxine, pyridoxal, pyridoxamine
(B6); biotin (B7); folic acid (B9); and cobalamin (B12) all offer unique benefits for human health.
Inhibitory effect of metformin and pyridoxamine
in the formation of early, intermediate and advanced glycation end-products," PLoS ONE, vol.
Vitamin B6 is a generic term that refers to the six interconvertible pyridine compounds (vitamers): pyridoxine (PN, commonly known as vitamin B6), pyridoxamine
(PM), pyridoxal (PL), and their 5'-phosphorylated forms (PNP, PMP, and PLP, resp.
Thiamine pyrophosphate and pyridoxamine
inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine.
In a later 2001 study, high concentration glucose solutions were used for generation of superoxide and it was demonstrated that 1 mM P or pyridoxamine
(PM) readily quenched superoxide to the range of 66% to 97%.
The newer therapies are on horizon like high doses of vitamin 6 Pyridoxamine
(derivative of Vit B6) orthophosphate Oxalate degrading bacteria as probiotics Bisphosphonates and sodium thio sulphate.
Vitamin B6 is a collective term for a group of three related compounds, pyridoxine, pyridoxal, pyridoxamine
, and their phosphorylated derivatives (30).
5 g; thiamin, 10 g; riboflavin, 10 g; pyridoxamine
, 12 g; cobalamin, 20 mg; nicotinamide, 40 mg; folic acid, 3 g; calcium pantothenate, 30 g; biotin, 100 mg; ascorbic acid, 60 g; and inositol, 60 g.
Oral and topical ingredients include botanical plant extracts, green tea polyphenols, an turmeric, algae extracts, quercetine, sily-marin, phloretin Flavanoids, pomegranate, blueberry, herbs and spices, as well as alpha-lipoic acid, aspirin, B vitamins, aminoguanidine, pyridoxamine
They also discuss the therapeutic potential of pyridoxamine
and benfotiamine; functions of biotin and gene transcriptional regulation through biotin and biotin-binding proteins; folate receptor-mediated therapeutics; vitamin B12 derivatives in tumor targeting; and the implications of ascorbic acid in different disorders.