In addition to the above-mentioned metabolites related to beef quality, changes over time were observed in the contents of key metabolites related to nutrition and beef aging: the relative contents of gluconic acid, gluconolactone, Cys-GTdS and coenzyme precursors including pyridoxamine
5'-phosphate (PMP) and thiamine significantly increased during postmortem aging of the beef (adjusted p<0.05, FDR<0.10; Figure 4).
Reactivity, Selectivity, and Reaction Mechanisms of Aminoguanidine, Hydralazine, Pyridoxamine
, and Carnosine as Sequestering Agents of Reactive Carbonyl Species: A Comparative Study.
The term vitamin [B.sub.6] refers to six common forms, namely pyridoxal, pyridoxine (pyridoxol), pyridoxamine
, and their phosphorylated forms.
inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat.
In agreement with similar dietary vitamin B-6 intakes between treatments and PKU genotype, no significant differences related to diet or genotype were found in plasma concentrations of pyridoxal and pyridoxate or urine concentrations of pyridoxal, pyridoxate, and pyridoxamine
. Additionally, plasma levels of pyridoxal and pyridoxate in PKU subjects were not different compared with controls.
Szefer, "Reversed-phase high-performance liquid chromatography method with coulometric electrochemical and ultraviolet detection for the quantification of vitamins B(1) (thiamine), B(6) (pyridoxamine
, pyridoxal and pyridoxine) and B(12) in animal and plant foods," Journal of Chromatography A, vol.
, nicanartine, zinc, selenium, pycnogenol, curcumin, taurine, and green tea have been found to have various free radical scavenging properties and has been useful in treatment of DR.
However, the oral treatment of pyridoxamine
(AGE inhibitor) ameliorated ROS production and inflammation in the discs of diabetic mice and consequently decelerated the progression of IDD [97, 98].
One of the most recently proposed pharmacological tools is pyridoxamine
, a structural analog of vitamin B6 that exerts antiglycative effect .
In addition, NN-(2-Acetamidooethyl) hydrozinecarboximidamide hydrochloride (ALT-946), 3-enzyloxycarbonylmethyl-4-methyl-thiazol-3-ium bromide (C36), Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) and pyridoxamine
are other substances that have been shown to reduce or prevent the harmful effects on the kidneys and cardiovascular system through AGE inhibition in experimental animals in different studies (35-39).
Especially, aminoguanidine (Pimagedine) and pyridoxamine
(Pyridorin) prevent diabetic nephropathy by inhibiting albuminuria, glomerular hypertrophy, and mesangial expansion in patients with type 1 diabetes (Bolton et al.
Baig et al., "Inhibitory effect of metformin and pyridoxamine
in the formation of early, intermediate and advanced glycation end-products," PLoS ONE, vol.