pyrimethamine

py·ri·meth·a·mine

(pī′rə-mĕth′ə-mēn′, -mĭn)

A folate antagonist, C₁₂H₁₃ClN₄, often administered in combination with a sulfonamide, used as an antimalarial and to treat toxoplasmosis.

[pyrim(idine) + eth(yl) + amine.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

pyrimethamine

(ˌpɪrɪˈmɛθəˌmiːn)

(Pharmacology) an antibiotic used to treat malaria. Formula: C12H13CIN4

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

Translations

pyrimethamine

n pirimetamina

Mentioned in ?

sulphadoxine

References in periodicals archive ?

Current treatment guidelines for toxoplasmic encephalitis (TE) (1) recommend either pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin; trimethoprim/sulfamethoxazole is also known to have comparable potency (2).

Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis

pyrimethamine and sulphadiazine in the country above mentioned drugs were used.

Toxoplasmosis in an Immunocompetent Patient

([double dagger]) Anti-toxoplasma treatment with sulfadiazine (50 mg/kg BD), pyrimethamine (2 mg/kg/day for 2 days, then 1 mg/kg 3 times a week for the rest of the treatment period), and folinic acid (10 mg 3 times a week).

Prenatal screening for congenital toxoplasmosis

The team believes triclosan could be employed as a drug against strains of malaria parasite that have grown resistant to a currently-used drug called pyrimethamine.

Toothpaste ingredient could help in malaria fight; SCIENCE

DHFR is already being targeted by pyrimethamine, a well-established anti-malarial drug, but resistance to the drug among malaria parasites is common, the researchers said.

'Robot scientist' finds that toothpaste ingredient could help fight against malaria; Researchers have used an artificially-intelligent robot called Eve to speed up drug development

DHFR is the target of the antimalarial pyrimethamine -- a drug to which malaria parasites are increasingly developing resistance, particularly in Africa.

Toothpaste ingredient could fight malaria

Many antimalarial agents, such as chloroquine, pyrimethamine, quinine, proguanil, sulfadoxine, and artemisinin have been used for malarial therapy.

Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

The samples comprised tablets, suspensions, injections, and mixtures containing sulphadoxine, pyrimethamine, quinine, lumefantrine, piperaquine, sulphamethoxypyridazine, artemether, artesunate, and dihydroartemisinin APIs.

Further Validation of a Rapid Screening Semiquantitative Thin-Layer Chromatographic Method for Marketed Antimalarial Medicines for Adoption in Malawi

Several drugs have been proposed for treatment, including pyrimethamine, sulfadiazine, spiramycin, clindamycin, and trimethoprim-sulfamethoxazole [8].

Intravitreal Clindamycin and Dexamethasone Combined with Systemic Oral Antitoxoplasma Therapy versus Intravitreal Therapy Alone in the Management of Toxoplasma Retinochoroiditis: A Retrospective Study

The use of pyrimethamine with sulfadiazine plus folinic acid has been one of the most used treatments in toxoplasmosis and is considered as first-line treatment [18].