Sodium ethylate is used in the production of various pharmaceutical products, including phenytoin, acetophenone phenylbutazone, aminopterin, cetazine, pyrimethamine
, pirafloxacin, tetracaine hydrochloride, etc.
Tenders are invited for call for quotations for the supply of pyrimethamine
Current treatment guidelines for toxoplasmic encephalitis (TE) (1) recommend either pyrimethamine
plus sulfadiazine or pyrimethamine
plus clindamycin; trimethoprim/sulfamethoxazole is also known to have comparable potency (2).
and sulphadiazine in the country above mentioned drugs were used.
([double dagger]) Anti-toxoplasma treatment with sulfadiazine (50 mg/kg BD), pyrimethamine
(2 mg/kg/day for 2 days, then 1 mg/kg 3 times a week for the rest of the treatment period), and folinic acid (10 mg 3 times a week).
The team believes triclosan could be employed as a drug against strains of malaria parasite that have grown resistant to a currently-used drug called pyrimethamine
DHFR is already being targeted by pyrimethamine
, a well-established anti-malarial drug, but resistance to the drug among malaria parasites is common, the researchers said.
DHFR is the target of the antimalarial pyrimethamine
-- a drug to which malaria parasites are increasingly developing resistance, particularly in Africa.
Many antimalarial agents, such as chloroquine, pyrimethamine
, quinine, proguanil, sulfadoxine, and artemisinin have been used for malarial therapy.
The samples comprised tablets, suspensions, injections, and mixtures containing sulphadoxine, pyrimethamine
, quinine, lumefantrine, piperaquine, sulphamethoxypyridazine, artemether, artesunate, and dihydroartemisinin APIs.
Several drugs have been proposed for treatment, including pyrimethamine
, sulfadiazine, spiramycin, clindamycin, and trimethoprim-sulfamethoxazole .
The use of pyrimethamine
with sulfadiazine plus folinic acid has been one of the most used treatments in toxoplasmosis and is considered as first-line treatment .