Sodium ethylate is used in the production of various pharmaceutical products, including phenytoin, acetophenone phenylbutazone, aminopterin, cetazine,
pyrimethamine, pirafloxacin, tetracaine hydrochloride, etc.
Tenders are invited for call for quotations for the supply of
pyrimethamine 25mg tablets
Current treatment guidelines for toxoplasmic encephalitis (TE) (1) recommend either
pyrimethamine plus sulfadiazine or
pyrimethamine plus clindamycin; trimethoprim/sulfamethoxazole is also known to have comparable potency (2).
pyrimethamine and sulphadiazine in the country above mentioned drugs were used.
([double dagger]) Anti-toxoplasma treatment with sulfadiazine (50 mg/kg BD),
pyrimethamine (2 mg/kg/day for 2 days, then 1 mg/kg 3 times a week for the rest of the treatment period), and folinic acid (10 mg 3 times a week).
The team believes triclosan could be employed as a drug against strains of malaria parasite that have grown resistant to a currently-used drug called
pyrimethamine.
DHFR is already being targeted by
pyrimethamine, a well-established anti-malarial drug, but resistance to the drug among malaria parasites is common, the researchers said.
DHFR is the target of the antimalarial
pyrimethamine -- a drug to which malaria parasites are increasingly developing resistance, particularly in Africa.
Many antimalarial agents, such as chloroquine,
pyrimethamine, quinine, proguanil, sulfadoxine, and artemisinin have been used for malarial therapy.
The samples comprised tablets, suspensions, injections, and mixtures containing sulphadoxine,
pyrimethamine, quinine, lumefantrine, piperaquine, sulphamethoxypyridazine, artemether, artesunate, and dihydroartemisinin APIs.
Several drugs have been proposed for treatment, including
pyrimethamine, sulfadiazine, spiramycin, clindamycin, and trimethoprim-sulfamethoxazole [8].
The use of
pyrimethamine with sulfadiazine plus folinic acid has been one of the most used treatments in toxoplasmosis and is considered as first-line treatment [18].
