pyrimidine


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py·rim·i·dine

 (pī-rĭm′ĭ-dēn′, pĭ-)
n.
1. A single-ringed, crystalline organic base, C4H4N2, that is the parent compound of a large group of biologically important compounds.
2. Any of a group of substituted derivatives of pyrimidine, including the nitrogen bases uracil, cytosine, and thymine, which are components of nucleic acids. Barbiturates and certain other drugs are also pyrimidines.

[Alteration of pyridine.]

pyrimidine

(paɪˈrɪmɪˌdiːn)
n
1. (Elements & Compounds) a liquid or crystalline organic compound with a penetrating odour; 1,3-diazine. It is a weakly basic soluble heterocyclic compound and can be prepared from barbituric acid. Formula: C4H4N2
2. (Elements & Compounds) Also called: pyrimidine base any of a number of similar compounds having a basic structure that is derived from pyrimidine, including cytosine, thymine, and uracil, which are constituents of nucleic acids
[C20: variant of pyridine]

py•rim•i•dine

(paɪˈrɪm ɪˌdin, pɪ-)

n.
1. a heterocyclic compound, C4H4N2, that is the basis of several important biochemical substances.
2. one of several pyrimidine derivatives, esp. the bases cytosine, thymine, and uracil, which are fundamental constituents of nucleic acids.
[1880–85;b. pyridine and imide]

py·rim·i·dine

(pī-rĭm′ĭ-dēn′)
Any of a group of organic compounds having a single ring with alternating carbon and nitrogen atoms. Pyrimidines include the bases cytosine, thymine, and uracil, which are components of nucleic acids.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.pyrimidine - any of several basic compounds derived from pyrimidine
alkali, base - any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia"
cytosine, C - a base found in DNA and RNA and derived from pyrimidine; pairs with guanine
T, thymine - a base found in DNA (but not in RNA) and derived from pyrimidine; pairs with adenine
2.pyrimidine - a heterocyclic organic compound with a penetrating odor
organic compound - any compound of carbon and another element or a radical
Translations
pyrimidine
References in periodicals archive ?
It can render DNA non-amplifiable through the formation of cyclobutane pyrimidine dimers and, to a lesser extent, what's known as the "6-4 photoproduct"; in either case, it's the creation of covalent bonds between adjacent bases on a DNA strand that disrupts their ability to hydrogenbond as needed to serve as a replication template.
Cytarabine is a pyrimidine analog which enters into the cells through a carrier process and then converted to its active compound, aracytidine triphosphate.
Specifically, niacinamide is known to enhance DNA excision repair and repair of UVB-induced cyclobutane pyrimidine dimers and UVA-induced 8-oxo-7,8-dihydro-2'-deoxyguanosine.
Specifically, nucleic acids or their constituent purine or pyrimidine bases act as internal microbial markers of microbial protein synthesis [2].
Ultraviolet (UV) solar radiation stimulates formation of DNA photoproducts--such as cyclobutane pyrimidine dimers--that are highly mutagenic and DNA-altering.
UVB acts directly inducing the formation of cyclobutane pyrimidine dimers and photoproducts (4-6).
The mode of action of this modality is by interfering with pyrimidine metabolism and converting to 5-fluro-2-deoxyuridine-5-phosphate (F-dump), which is potent inhibitor of thymidylate synthetase, thus DNA synthesis is blocked.
223501438 siderophore group nonribosomal peptides pae00240: Pyrimidine metabolism 11 2.
The immunomodulating effects of leflunomide may be related to its selective inhibition of de novo pyrimidine synthesis.
3 lactones, neog, heterocyclic compounds only hetero-atom (s) of nitrogen, with the structure of noncondensable pirazynove ring, pyrimidine ring or ring piperazolne phenothiazine ring system not further condensation; hydantoin and its derivatives; sulphonamides (medicines)
The remaining 38 agents can be classified into the following categories: anticoagulant (2), antidiarrheal (1), antidiabetic (1), antidote (3), antiemetic (1), antifungal (1), antilipemic (2), antineoplastic (13), antipsychotic (2), antiviral (1), bile acid (2), cardiovascular (2), female sexual dysfunction (1), immunomodulator (1), lysosomal acid lipase deficiency (1), parathyroid hormone (1), pyrimidine analog (1), and respiratory (2).
Results of quantitaion of Purine and Pyrimidine bases using Ethyl Chloroformate as Derivatizing Reagent.