Also found in: Thesaurus, Medical.


 (pī′rō-jĕn′ĭk) also py·rog·e·nous (pī-rŏj′ə-nəs)
1. Producing or produced by fever.
2. Caused by or generating heat.
3. Of or relating to solid rock formed from molten rock; igneous.

py′ro·ge·nic′i·ty (-rō-jə-nĭs′ĭ-tē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Medicine) med the characteristic of causing fever
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Use of a Biological Assay to Mitigate Vaccine Pyrogenicity (C.
There were also 27,249 pyrogenicity tests and 578,948 batch potency tests (a proportion of which is likely to include botulinum toxin batch tests (see Taylor et al., 2019)).
Earlier in 2017, the company received long-term implantation results from parts 3, 10, 6 and 11 of the ISO 10993 (Biological Evaluation of Medical Devices) suite of tests, which include evaluation of genotoxicity, sub-chronic systemic toxicity and pyrogenicity. The LQMT alloy LM105 passed all of these tests well within the allowable limits.
A few examples of such processes are: acid treatment and microwave radiation, resulting in a reduction from 10 to 3 kDa, but with the disadvantage of high cost and residual acidity [33] ; irradiation at different temperatures in acid medium for 35 days to achieve a reduction from 71 to 21 kDa [10]; and enzymatic reactions using proteases such as papain, a cysteine protease, keeping in mind, however, that a high level of pyrogenicity may occur due to the presence of proteins mixed with the end product [8], as the focus of application is biomedical.
Included are cytotoxicity, sensitization, intracutaneous reactivity, acute systemic toxicity, implantation (two, 12, and 26 weeks), hemocompatibility (hemolysis and PPT), and pyrogenicity. Parylenes N, C, and HT are also certified to comply with the biological testing requirements for USP Class VI Plastics.
Pyrogenicity tests: Implants, as well as sterile devices, should meet pyrogen limit specifications.
Among his topics are pyrogenicity and bacterial endotoxin, electron beam processing, hydrogen peroxide vapor sterilization, cleaning and disinfecting sterile processing facilities, and auditing sterilization processes and facilities.
Tilcock, "Studies upon the toxicity of polyethylene glycol coated lipid vesicles: acute hemodynamic effects, pyrogenicity and complement activation," Journal of Liposome Research, vol.
Kozak, "Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-[kappa] B," American Journal of Physiology, vol.