Among the observed compounds, L2 with pyrrolidine
moiety demonstrated no antioxidant activity; on the contrary, it demonstrated an oxidant activity.
A study has documented that pyrrolidine
dithiocarbamate (PDTC), an antioxidant, specifically suppresses NF-kB activation (10).
Spider silk is mainly composed of Glycine, Alanine and large amount of pyrrolidine
. These amino acids maintain the moisture of spider silk and prevent it from drying out.
Moreover, SA was used as a simple organocatalyst for the synthesis of diarylmethanones , [alpha]-aryl ketones , pyrrolidine
derivatives , 2,3-dihydroquinazolin-4(1H)-ones , homoallylic alcohols  as well as 3,3'-bis(indolyl)methanes (BIMs) .
Butterbur root, prepared to remove all liver-toxic pyrrolidine
alkaloids (sold as Petadolex), boasts the most research for allergies and sinus-related conditions (albeit primarily funded by its manufacturers).
(26) reported that TGF-[beta]-induced p38 activation was mediated by the Rac1-regulated generation of ROS in cultured human keratinocytes; nonetheless, the authors observed that DPI and pyrrolidine
dithiocarbamate (known as an antioxidant) had no inhibitory effects on the TGF-[beta] induced phosphorylation of Smad2.
All chemicals including Cd[(NO3).sub.2] (Merck Co.), Ammonium Pyrrolidine
dithiocarbamate (APDC) (Sigma Aldrich Co.), and Tween 80 (Sigma Aldrich Co.) were of guaranteed laboratory grade reagents.
Dichloromethane, N-methyl pyrrolidine
, dimethyl acetamide, and triethylamine were purchased from E-Merck Limited, India.
Those taking pyrrolidine
alkaloids should avoid butterbur, but it otherwise can help prevent migraine when dosed at 50-75 mg daily divided up into 2-3 for ages 8-9 years and 100-150 mg daily divided up into 2-3 for ages 10-17 years.
Tanaka et al., "Pyrrolidine
dithiocarbamate provides protection against hypothermic preservation and transplantation injury in the rat liver: the role of heme oxygenase-1," Surgery, vol.
ring of the ligand is represented with a solid line for clarity.
Chen, "Effects of the NF-[kappa]B inhibitor pyrrolidine
dithiocarbamate on experimentally induced autoimmune anterior uveitis," Investigative Ophthalmology & Visual Science, vol.