ENPNewswire-September 5, 2019--Agios Announces Publication of Data for Mitapivat from Core and Extension Phases of the DRIVE PK Study in Patients with Pyruvate
Agios Pharmaceuticals announced that new data from the core and extension phases of the DRIVE PK Phase 2 study of mitapivat in adults with pyruvate
kinase, or PK, deficiency were published in the September 5 issue of the New England Journal of Medicine, or NEJM.
In the present study, DEGs were enriched in amino acid metabolism pathways include GOT1, MDH1, monocarboxylate transporter 4 (SLC16A3), pyruvate
dehydrogenase 1 (PDHA1), and pyruvate
dehydrogenase kinase 4 (PDK4).
Keywords: Hypoxic-ischemic encephalopathy, Molybdenum cofactor deficiency, Pyruvate
carboxylase deficiency, Zellweger syndrome, Non-ketotichyperglycinaemia.
The samples of the effluent fluid of the perfusion were used to determine glucose and total nitrogen by enzymatic-colorimetric methods (Gold Analisa[R]) and lactate and pyruvate
through enzymatic methods.
Qu and his colleagues have been studying an enzyme, PTPMT1, which controls the influx of pyruvate
-- a source of energy derived from carbohydrates -- into mitochondria.
One of its primary purposes is to feed the baby, and to do so, it is filled with proteins, carbohydrates, lipids, peptides, taurine, glutamine, lactate, pyruvate
, electrolytes, hormones and enzymes.
The effects of fornix DBS on extracellular glucose, lactate, pyruvate
, and glutamate levels over time were analyzed by repeated-measures analysis of variance followed by Fisher's least significant difference post hoc test.
Preclinical studies of additional bone marrow-derived disorders are ongoing and target pyruvate
kinase deficiency, leukocyte adhesion deficiency-I (LAD-I) and infantile malignant osteopetrosis.
In the article titled "Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced [alpha]-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species" , there was an error in Figure 1, in which the decarboxylation of pyruvate
to acetyl-CoA should be accompanied by NAD to NADH, not NADH to NAD.
For the polarization of pyruvate
, a 35 [micro]L of [1-[sup.13]C]-pyruvate mixed with 15 mM OX063 trityl radical (GE Healthcare, Oslo, Norway), and 1.5 mM gadolinium (Gd)-DOTA was polarized using a HyperSense[R] (Oxford Instruments, Abingdon, UK) [7,10].