The small molecules are further classified into pentosan polysulfate, quinacrine
, amphotericin B, and others.
The correct use of an old malaria drug, "quinacrine
," has been one of those discoveries.
It is a dimeric form of the antimalarial drug quinacrine
- meaning it has two molecules of quinacrine
bound together with a special linker.
A switch to chloroquine, or adding quinacrine
, might do the trick, saving at least some patients from having to move on to immunosup pressive therapy, Dr.
Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine
fluorescence and Giemsa staining.
Atabrine: A synthetic antibiotic developed by the German pharmaceutical company Bayer in 1931, Atabrine (the trade name for mepacrine, also called quinacrine
) was the first manmade substitute for quinine, the anti-malarial drug of choice at that time.
Rowley, "A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine
fluorescence and Giemsa staining," Nature, vol.
Croft, Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine
Tariq, "Protective effect of quinacrine
against glycerol-induced acute kidney injury in rats," BMC Nephrology, vol.
Ajarem, "The effects of quinacrine
, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus," Oxidative Medicine and Cellular Longevity, vol.
The research in animals has proved that curcumin and quinacrine
liposomes not only could enhance apoptosis effects and endocytic effects of C6 glioma stem cells in vitro, but also could increase the survival period of brain glioma-bearing mice and inhibit the growth of gliomas in vivo .
Sharma, "Variability in cytogenetic adaptive response of cultured human lymphocytes to mitomycin C, bleomycin, quinacrine
dihydrochloride, Co60 y-rays and hyperthermia," Mutagenesis, vol.