Several pharmaceutical formulations and supplements are manufactured with racemate
(DL-carnitine), although only the levorotatory form is biologically active (Sanchez-Hernandez et al., 2010a, 2010b; Dqbrowska & Starek, 2014).
compound with a pair of cis/trans has DF=0.5 or 50%, while with two pairs, has DF=0.25 or 25% for each diastereomer.
The plasma concentration of free (Unbound) levobupivacaine is lower than that of bupivacaine racemate
, because of greater protein binding of the levorotatory enantiomer.
The affinity ([IC.sub.50] = 50 nM) of the racemate
of BV to VAChT is similar to that ([IC.sub.50] = 40 nM) of the racemate
of vesamicol in the in vitro binding assay .
It should also be noted that a mismatch in the chemical shifts of the signals for each enantiomer with respect to racemate
is explained by different amounts of the sample compounds loaded into a vial and the shift reagent.
In SESA trial, edema was resolved in 98.72% patients after switching from racemate
amlodipine to S-AM .
The single crystal XRD also confirms the structure of iodo product 13 and indicates the product to be a racemate
of RandS isomers (figure 3).
1) from Cecropia moth and its structure was established by Trost by the synthesis of its racemate
. (5) Later studies revealed JHs to be a group of epoxy esters generated by homologation and epoxidation of methyl farnesoate.
Similar results are obtained but show different pharmacokinetic characteristics of dextroisomer and racemate
in dihydromyricetin: [C.sub.max] (81.3 and 107 ng/mL), AU[C.sub.0-[infinity]] (42.8 and 32.0 mg x min/L), and [t.sub.1/2] (288 and 367 min), respectively .
To develop a single stereoisomer from a mixture that has already been studied non-clinically, an abbreviated, appropriate pharmacology/toxicology evaluation could be conducted to allow the existing knowledge of the racemate
available to the sponsor to be applied to the pure stereoisomer....
Werner, "From the racemate
to the eutomer: (S)-ketamine.