raloxifene


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ra·lox·i·fene

 (rə-lŏk′sĭ-fēn′)
n.
A selective estrogen receptor modulator, C28H27NO4S, used in the form of its hydrochloride primarily to treat and prevent osteoporosis in postmenopausal women.

[ral-, of unknown origin + (eth)oxy + alteration and blend of phen(yl) and -ene.]

ra•lox•i•fene

(rəˈlɒk səˌfin)
n.
a drug, C28H27NO4S, prescribed primarily to prevent postmenopausal osteoporosis.
Translations

raloxifene

n raloxifeno
References in periodicals archive ?
The researchers found that tamoxifen, raloxifene, and the aromatase inhibitors exemestane and anastrozole correlated with a reduced incidence of invasive breast cancer in placebo-controlled trials (risk ratios, 0.69, 0.44, and 0.45, respectively).
(5) Thus, it is evident that, in the endometrium, ospemifene is much more like the SERM raloxifene than it is like estrogen.
Contract award notice: Tender for the supply of finasteride and raloxifene (cyprus-nicosia: Medicinal products for the genitourinary system and sex hormones)
Raloxifene is a SERM that acts as an estrogen agonist in some tissues, but an antagonist in uterine and breast tissue, which may minimize potential deleterious adverse effects (Table 2, (21-24) page 49).
We report the case of a woman who suffered spontaneous clinical vertebral fractures at denosumab discontinuation despite a preventive treatment with raloxifene.
The members of the benzothiophene class of SERMs include raloxifene, arzoxifene, bazedoxifene, and lasofoxifene, which are used primarily for the treatment of osteoporosis; however, raloxifene has also been approved for the treatment of breast cancer in high-risk postmenopausal women [23-25].
The American College of Physicians' updated clinical practice guideline for treating osteoporosis strongly advocates bisphosphonates and strongly advises against estrogens or raloxifene. It was presented online May 8 in Annals of Internal Medicine.
Estrogens or raloxifene are not advised for established osteoporosis, because good evidence shows they do not reduce fracture risk, according to the guideline.
The cost watchdog has advised that doctors prescribe either tamoxifen, raloxifene or anastrozole to hundreds of thousands of 'healthy' women who may not have a personal history of the disease, but are at a heightened risk of developing it.
The second SERM generation includes raloxifene, and newer SERM molecules are bazedoxifene, lasofixene, teremifene, ospemifene and arzoxifene [22, 23].
The osteoporosis drug raloxifene (Evista) failed to improve memory and thinking skills in women with Alzheimer's disease (AD), according to a study published online Nov.
Raloxifene (raloxifene hydrochloride), a non-hormone drug against bone resorption, belongs to the second generation of selective estrogen receptor modulator (SERMs).