AMR-MeOAc treatment reduced Ras activation in a time-dependent manner, while it did not affect total Ras protein
We also showed that let-7 was produced at low concentrations in lung tumor samples relative to those of normal lung tissue from the same patient, whereas the concentration of RAS protein
was significantly higher in lung tumors.
Following a weak signal, not enough of the Ras protein
is activated, so the T cell won't take any action.
Found in 30 percent of all human cancer tumours, the Ras protein
literally 'drives cells crazy,' says Prof.
8,9] In the study by Freer et al, normal mucosa and verrucous carcinoma showed significant expression of p21 Ras protein
, but a marked decrease in the detectable amounts of this protein in more undifferentiated cells.
The Roswell Park researchers worked with investigators from the National Cancer institute to design the study, basing their assumptions on preclinical evidence that a special vaccine against this mutant RAS protein
could effectively "jump-start" a weakened immune system to fight the disease.
A molecular biologist who is internationally renowned for his work on the RAS signaling pathway, McCormick is leading the National Cancer Institute s RAS Project, a new laboratory that will focus on the mutated RAS protein
, which plays a key role in a third of all cancers.
The TAU researchers are trying to discover the mechanisms whereby the Ras protein
is transferred, and their initial findings seem to be promising.
Induction of ras protein
was analysed by Western blotting.
Salirasib is the first in a new class of compounds called "rasibs" that inhibit overactive cell growth due to a mutation of the Ras protein
These researchers searched fruitlessly for an antidote to the Ras protein
for almost a decade, recalls Allen Oliff, executive director for cancer research at Merck.