Ras protein


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Related to Ras protein: GTPase, G protein

Ras protein

or ras protein  (răs)
n.
Any of a group of proteins that are found near cell membranes and regulate cell division and proliferation. Abnormal Ras proteins facilitate uncontrolled cell division, leading to the development of tumors.

[ra(t) s(arcoma), from the fact that genes coding for abnormal ras proteins were first isolated from rat sarcomas.]
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A new study has discovered how Ras protein binds itself to cell membranes impacting the signaling pathways that cause cancer's uncontrolled growth.
By initiating EGFR are transported from the cytosol to the plasma membrane or Golgi apparatus, where the effectors are located along the Ras protein.
Mutations in any of these codons lead to a constitutively activated RAS protein.
Mutational analysis of Kras and Ras Protein expression in larynx squamous cell carcinoma J.
AMR-MeOAc treatment reduced Ras activation in a time-dependent manner, while it did not affect total Ras protein expression (Fig.
We also showed that let-7 was produced at low concentrations in lung tumor samples relative to those of normal lung tissue from the same patient, whereas the concentration of RAS protein was significantly higher in lung tumors.
Following a weak signal, not enough of the Ras protein is activated, so the T cell won't take any action.
Small G proteins (also called small GTPases, small GTP binding proteins and Ras protein superfamily) comprise a wide variety of proteins that share the same architecture of their GTP-binding domain.
One specific intracellular signaling protein worth mentioning is the Ras protein group.
The Roswell Park researchers worked with investigators from the National Cancer institute to design the study, basing their assumptions on preclinical evidence that a special vaccine against this mutant RAS protein could effectively "jump-start" a weakened immune system to fight the disease.
A molecular biologist who is internationally renowned for his work on the RAS signaling pathway, McCormick is leading the National Cancer Institute s RAS Project, a new laboratory that will focus on the mutated RAS protein, which plays a key role in a third of all cancers.