A team of researchers from the University of Texas at Dallas restricted the levels of circulating glucose in mice by feeding them a ketogenic diet and administering a diabetes drug that stops the reabsorption
of blood sugar in the kidneys.
Kidney and cardiovascular specialists conducted a pilot study in 19 patients to show that the higher doses of spironolactone, which prevented reabsorption
of excess salt in the kidneys and maintained potassium levels, could be used safely in these very-ill patients, who were admitted to the hospital with heart failure exacerbation and don't respond to conventional diuretics.
The renal tubules have specialised features that allow the reabsorption
and secretion of solutes, and osmosis of water, as the urinary filtrate travels from the glomerulus to the collecting ducts and then out of the kidney.
When it comes to kidney organoids, that shortcoming has kept researchers from reproducing key functions, such as blood filtration, reabsorption
, and urine production.
In kidney, AQP1 is localized in the plasma membranes of proximal tubules, descending thin limbs of Henle's loop and descending vasa recta where it appears to be the main site for water reabsorption
in the proximal nephron (Nielsen et al.; Zhai et al.; Kortenoeven & Fenton).
Inactivating autosomal recessive mutations in FGF23, KL or the GALNT3 genes lead to increased renal tubular phosphate reabsorption
and, usually, elevated 1,25-dihydroxyvitamin [D.sub.3] (l,25-[OH.sub.2][D.sub.3]), promoting gastrointestinal absorption of calcium and phosphorus (1, 3, 4).
Sotagliflozin is an investigational oral dual inhibitor of two proteins responsible for glucose regulation known as sodium-dependent glucose co-transporter types 1 and 2.1 SGLT1 is responsible for glucose absorption in the gastrointestinal tract,2 and SGLT2 is responsible for glucose reabsorption
by the kidney.
In one study, it was found that those osteoporotic patients who took thiazide diuretic had 0.87 times the risk of having fractures compared to those who did not take the drug.2 Proposed mechanism through which Thiazide diuretic decreases the risk of having fracture is by not only increasing calcium reabsorption
by the kidney but also by inhibiting sodium-chloride cotransport in osteoblast thus increasing calcium levels in the bones.3
To well understand the mechanisms on sweat secretion and reabsorption
, the differential innervation of secretory coils and ducts in human eccrine sweat glands was investigated in the study.
The researchers attribute the variations in the UHI effects to differences in the radiation and reabsorption
of heat by adjacent buildings in urban areas.
THURSDAY, May 24, 2018 (HealthDay News) -- For children with X-linked hypophosphatemia, subcutaneous burosumab is associated with decreases in rickets severity and with improved renal tubular phosphate reabsorption
, according to a study published in the May 24 issue of the New England Journal of Medicine.