The Top 5 most likely to cause somnolence, compared with placebo, are fluvoxamine, mirtazapine, reboxetine
, paroxetine, and desvenlafaxine.
Classic antidepressants reboxetine
, amitriptyline and rice oxaprozin all played antidepressant role through regulating MAPK/ERK signaling pathway (Di Benedetto et al.
The authors report that a reduction in the BDI and Hamilton Depression Scale was observed in both the treatment and placebo groups; however, the reduction in the group treated with reboxetine
was the only statistically significant change (Rampello et al.
Comparison of reboxetine
and sertraline in terms of efficacy and safety in major depressive disorder.
Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine
analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine.
18-20) Emerging data suggest that the newer antidepressants such as escitalopram, (21,22) reboxetine
, (23,24) nefazodone, (25) venlafaxine, (26) mirtazapine (27-29) and buproprion (30-32) are promising alternatives.
Citing the unpublished studies, the researchers called reboxetine
"an ineffective and potentially harmful antidepressant.
Experts measured the impact of "publication bias" in clinical trials of reboxetine
carried out for predecessors of Pfizer, which makes Edronax.
bupropion, flupenthixol, fluphenazine, mirtazapine, reboxetine
, sulpiride, trazodone and perphenazine/nortriptyline combination).
The review included the following drugs: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, mirtazapine, paroxetine, reboxetine
, sertraline, and venlafaxine (Lancet 2009 [doi: 10.
Eighteen drugs are in Phase III development in the US including two GABA receptor agonists pregabalin (Pfizer) and gabapentin GR (Depomed); a sodium channel antagonist mexiletine (Boehringer Ingelheim); three glutamate / NMDA antagonists ketamine intranasal (Javelin), a dextromethorphan/quinidine combination (Avanir), and NP-1 (EpiCept/Epitome); two serotonin/norepinephrine reuptake inhibitors desvenlafaxine (Wyeth), and paroxetine (GSK/Novo Nordisk); an alpha-2 adrenergic receptor antagonist/norepinehrine reuptake inhibitor reboxetine
(Pfizer); an opioid receptor agonist/norepinephrine reuptake inhibitor tapentadol (Ortho-McNeil); a dopamine receptor agonist sodium oxybate (Jazz), and a neuromuscular blocking agent botulinum toxin A (Allergan).
is a selective norepinephrine reuptake inhibitor used in the United Kingdom.