receptor modulator


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receptor modulator

n.
A substance that acts on a chemical receptor, usually as an agonist, antagonist, or combination of both: a selective estrogen receptor modulator; a nicotine receptor modulator.
References in periodicals archive ?
NYX-2925 is an oral, small-molecule NMDA receptor modulator that binds to a novel site on the NMDA receptor and enhances synaptic plasticity to restore normal neural cell function.
According to the company, ulipristal acetate, which is an investigational drug in the US for the medical treatment of abnormal uterine bleeding in women with uterine fibroids, is a selective progesterone receptor modulator (SPRM), which acts directly on the progesterone receptors in three target tissues.
Ozanimod is a novel, oral, selective sphingosine 1-phosphate 1 and 5 receptor modulator.
Efficacy and safety of the selective progesterone receptor modulator (PRM) vilaprisan data from the phase 2 ASTEROID 2 study presented by Kristina Gemzell-Danielsson in the oral presentation session Gynecology: Myoma and Endometriosis on Friday, October 20, 2017: 05:00 PM to 06:30 PM Room B
Celgene's Phase III SUNBEAM trial, evaluating the efficacy and safety of ozanimod, an investigational oral, selective S1P 1 and 5 receptor modulator, in patients with relapsing multiple sclerosis (RMS), met the primary endpoint in reducing annualized relapse rate (ARR), compared to weekly interferon (IFN) [beta]-1a (Avonex).
Naurex, which focuses on developing treatments to address unmet needs in psychiatry and neurology, said it would use the proceeds to fund a number of key programmes from its NMDA receptor modulator platform, including a Phase Ilb trial of GLYX-13, its lead NMDA receptor modulator in development for the treatment of depression.
An FDA advisory panel unanimously agreed that the selective progesterone receptor modulator ulipristal acetate is an effective emergency contraceptive with an acceptable safety profile, when used within 5 days of unprotected intercourse or a known or suspected contraceptive failure.
Soybeans contain a compound daidzein that certain bacteria living within the digestive tract of some individuals can metabolize, or convert, into Natural S-equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman], a compound thought to act as a selective estrogen receptor modulator (SERM).
Pharmacopeia (Princeton, CA), an innovator in the discovery and development of novel small molecule therapeutics, announced that it has licensed from Bristol-Myers Squibb (New York, NY) a selective androgen receptor modulator (SARM) program, including a lead compound in Phase 1 clinical development and back-up compounds.
Progesterone receptor modulator CDB-2914 down regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphateribose) polymerase expression in cultured human uterine leiomyoma cells," Journal of Clinical Endocrinology& Metabolism 90(2): 953-961.
Raloxifene is a selective estrogen receptor modulator, specifically developed to maintain beneficial estrogenic activity on bone and lipids and antiestrogenic activity on endometrial and breast tissue.
Clomiphene, a selective estrogen receptor modulator (SERM) is one of the most widely used infertility drugs and has long been used to induce ovulation in women trying to conceive.

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