Applied Therapeutics announced the initiation of a Phase 3 registrational trial for AT-001, a novel, potent and selective aldose
reductase inhibitor, in Diabetic Cardiomyopathy.
Now there are three classes of medications: alpha blockers (Tamsulosin and others), 5-alpha
reductase inhibitors (Finasteride and others) and the phosphodiesterase-5 Inhibitor Tadalafil.
Aldose
reductase (AR) (EC 1.1.1.21) is expressed by the AKR1B1 gene in humans.
However, its concentration is reduced to less than 1% by the cytochrome-b5
reductase enzyme system; namely, the intracellular MetHb reductive system.
Among the micronutrients, the molybdenum (Mo) presents a great importance to the plant, since its function is related to the biological nitrogen fixation, acting as a co-factor of the nitrate
reductase enzyme, which acts in the reduction of the nitrate to ammonium, in the plant (Araujo et al.
Autodock was used to perform the docking simulations employing the 3D structure of E.coli enoyl
reductase (PDB code: 1C14).
According to the company, the OBI-3424 is a first in class DNA alkylating cancer therapeutic agent targeting aldo-keto
reductase 1C3 (AKR1C3) overexpressing cancers.
Objectives: To investigate the association of methylenetetrahydrofolate
reductase gene 677C>T polymorphism with post-stroke depression risk and antidepressant treatment response in Han Chinese.
(1) entitled Methylenetetrahydrofolate
reductase (MTHFR) deficiency: The hidden risk in paediatric anaesthesia.
Thioredoxin (Trx), nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin
reductase (TrxR) comprise a thioredoxin system which exists in nearly all living cells (Arner and Holmgren 2006).
Diabetic complications including neuropathy, nephropathy, cataracts, and retinopathy are considered to be caused by the accumulation of sorbitol, which is produced from glucose by aldose
reductase in the polyol pathway [2].
The latter organisms lack the typical glutathione
reductase (GR) and TR enzymes, and TGR is the only disulfide
reductase involved in the regeneration of the reduced state of both thioredoxin (trx) and glutathione.
