Applied Therapeutics announced the initiation of a Phase 3 registrational trial for AT-001, a novel, potent and selective aldose reductase
inhibitor, in Diabetic Cardiomyopathy.
Now there are three classes of medications: alpha blockers (Tamsulosin and others), 5-alpha reductase
inhibitors (Finasteride and others) and the phosphodiesterase-5 Inhibitor Tadalafil.
(AR) (EC 188.8.131.52) is expressed by the AKR1B1 gene in humans.
However, its concentration is reduced to less than 1% by the cytochrome-b5 reductase
enzyme system; namely, the intracellular MetHb reductive system.
Among the micronutrients, the molybdenum (Mo) presents a great importance to the plant, since its function is related to the biological nitrogen fixation, acting as a co-factor of the nitrate reductase
enzyme, which acts in the reduction of the nitrate to ammonium, in the plant (Araujo et al.
Autodock was used to perform the docking simulations employing the 3D structure of E.coli enoyl reductase
(PDB code: 1C14).
According to the company, the OBI-3424 is a first in class DNA alkylating cancer therapeutic agent targeting aldo-keto reductase
1C3 (AKR1C3) overexpressing cancers.
Objectives: To investigate the association of methylenetetrahydrofolate reductase
gene 677C>T polymorphism with post-stroke depression risk and antidepressant treatment response in Han Chinese.
(1) entitled Methylenetetrahydrofolate reductase
(MTHFR) deficiency: The hidden risk in paediatric anaesthesia.
Thioredoxin (Trx), nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase
(TrxR) comprise a thioredoxin system which exists in nearly all living cells (Arner and Holmgren 2006).
Diabetic complications including neuropathy, nephropathy, cataracts, and retinopathy are considered to be caused by the accumulation of sorbitol, which is produced from glucose by aldose reductase
in the polyol pathway .
The latter organisms lack the typical glutathione reductase
(GR) and TR enzymes, and TGR is the only disulfide reductase
involved in the regeneration of the reduced state of both thioredoxin (trx) and glutathione.