However, owing to its advantages in efficacy and safety and tolerability, Novartis's relaxin
will displace furosemide and will earn Decision Resources' proprietary clinical gold-standard status for acute heart failure in 2019, following its launch for the indication in 2014.
today announced that the results and additional statistical analyses conducted from Pre-RELAX-AHF, the Phase II portion of a Phase II/III multicenter, randomized, double-blind, international study, showed that relaxin
, the company's investigational drug for the treatment of acute heart failure (AHF), was the strongest independent predictor of improved longer-term outcomes following hospital discharge when compared to other variables.
In pigs, rats, and mice, relaxin
promotes growth and softening of the cervix, enabling rapid and safe delivery of the fetuses.
TEL-AVIV, Israel -- Compugen (NASDAQ:CGEN) announced today that CGEN-25009, a novel peptide that previously demonstrated the ability to activate the Relaxin
receptor LGR7 (RXFP1) in cell based assays, has shown positive therapeutic effects in an animal model of pulmonary fibrosis.
The data from 234 patients in eight countries showed that when administered with standard-of-care therapy for acute heart failure, relaxin
caused rapid, substantial and sustained relief from dyspnea (breathlessness).
TEL AVIV, Israel -- Speaking before the 5th International Conference on Relaxin
and Related Peptides in Maui, Hawaii, Dr.
When the platypus genome became available for study, Hsu was eager to compare the sequence of their relaxin
genes with that of relaxin
family members from fish, birds, marsupials and placental mammals.
today announced that an interim analysis of top-line data from Pre-RELAX-AHF, the Phase II portion of a Phase II/III multicenter, randomized, double-blind, international study, showed favorable efficacy and safety for relaxin
, the company's investigational drug for treatment of acute heart failure.
10 after admitting that a skin treatment called Relaxin
failed to work in tests.
The receptors for which novel ligands have been discovered include the MAS1 and MAS-related GPCRs, MRGX1 and MRGX2, as well as FPRL1 and two of the Relaxin
family receptors, RXFP1 and RXFP2.
3 /PRNewswire/ -- Top-line preliminary data from a Phase II/III clinical trial of Corthera's investigational drug relaxin
for the treatment of acute heart failure will be presented next week at a satellite symposium at the American Heart Association's (AHA) Scientific Sessions 2008 in New Orleans.
During pregnancy there's an increase in hormones, including relaxin
, which softens up the ligaments in preparation for the birth.