Achieving the best metabolic control (HbA1c <7%), treating hypertension (<130/80 mmHg or <125/75 mmHg if proteinuria >1.0 g/24 h and increased serum creatinine), using drugs with blockade effect on the rennin
angiotensin aldosterone system and treating dyslipidaemia (LDL cholesterol <100 mg/dl) are effective strategies for preventing the development of microalbuminuria, in delaying the progression to more advanced stages of nephropathy and in reducing cardiovascular mortality in patients with type 1 and type 2 diabetes.
Decrease in blood volume is a powerful stimulus for rennin
secretion (Hazon and Flik, 2002).
The fluid was aseptic and chylous with lymphocytes and protein and rennin
specific to kidneys.
To this is added the well-recognized sequelae of heart failure like increased salt and water retention secondary to increased rennin
and aldosterone production, impaired visceral, splanchnic and renal perfusion and increased catecholamine levels, which in time produce significant down regulation of beta receptors and diminished myocardial catecholamine stores.
This could be due to increased sympathetic activity or elevation of circulating catecholamine while other active hormone like rennin
, angiotensin aldosterone also contribute, Rise in blood pressure due to stress leads to increased epinephrine secretion Rise in blood pressure is important sympatho-adrenal response to physiological stressful experience caused by premenstrual stress.
Human fetal kidney morphometry during gestation and the relationship between weight, kidney morphometry and plasma active rennin
concentration as birth.
Several mechanism have been postulated for the effect of calcium on blood pressure, a low calcium intake increases blood pressure through stimulating rennin
release, which in turn causes vasoconstriction, another possible mechanism is through lowering parathyroid release and intracellular calcium resulting in smooth muscle contractility.
Reports suggest that a positive relationship between plasma angiotensin level, plasma rennin
activity, and plasma angiotensin converting enzyme with BMI exits in humans.
The plasma aldosterone level is normal or high, and plasma rennin
activity (PRA) is low.
was analysed on DIASORIN LIASONA(r) by sandwich chemiluminescence immunoassay and analysis of serum aldosterone was done by BIORAD PhD(tm) SYSTEM-enzyme-linked immunosorbent assay (ELISA).
It is well established that maternal diet induced-hypertension is related to mechanisms that include reduced nephron morphology and function, reduced glomerular filtration rate, dysfunction on the rennin
angiotensin-aldosterone system (9), as well as sympathetic-respiratory dysfunctions (10).
Hypertension, associated with dyslipidemia, can be found in AAS users, and this can be a result of hyperactivation of adrenal cortex and rennin
secretion increase (19).