(redirected from replicative senescence)
Also found in: Thesaurus, Medical, Encyclopedia.


1. Growing old; aging.
2. No longer dividing. Used of a cell.

[Latin senēscēns, senēscent-, present participle of senēscere, to grow old, inchoative of senēre, to be old, from senex, sen-, old; see sen- in Indo-European roots.]

se·nes′cence n.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.senescence - the organic process of growing older and showing the effects of increasing agesenescence - the organic process of growing older and showing the effects of increasing age
catabiosis - normal aging of cells
biological process, organic process - a process occurring in living organisms
2.senescence - the property characteristic of old agesenescence - the property characteristic of old age
oldness - the opposite of youngness


Old age:
age, agedness, elderliness, senectitude, year (used in plural).


n (form)Alterungsprozess m, → Seneszenz f (spec)


n. senescencia, senectud, proceso de envejecimiento.
References in periodicals archive ?
Telomeres shorten with each cell division eventually leading to replicative senescence, a process thought to be associated with age-related decline in immune function.
However, MSC have a limited lifespan in vitro, exhibiting a progressive reduction in their capacity for self-renewal that usually ends in the irreversible arrest of cell division or replicative senescence [29, 30].
Cellular senescence resulting from repeated cellular replication is called "replicative senescence" [13, 14].
Unlike cells with limited number of divisions, immortal cells do not undergo replicative senescence. However, it was shown that they are prone to stress-induced senescence [71, 72].
This phenomenon, the "Hayflick limit" [43], also known as replicative senescence, restricts the life span in vitro of all primary mammalian somatic cells.
However, as MSCs are expanded, they undergo replicative senescence [15-17] and demonstrate morphological abnormalities, enlargement [18, 19], more podia and actin stress fibers [18, 20], less expression of specific surface markers, and decreased proliferation and differentiation [21-28].
Replicative senescence was used as an in vitro surrogate for aging [15].
Several factors lead to senescence, and one of them is the cellular division, with telomere shortening, called replicative senescence [23, 24].
Epigenetic modifications leading to chronic inflammation have been described in ECs and immune cells of diabetes patients also in the absence of replicative senescence biomarkers [23, 57, 58].
However, MSCs undergo replicative senescence, limiting the number of divisions [39-41].
The cell senescence has indicated the irreversible G1 growth arrest of normal primary cells, which occurs after the cells have accumulated time-dependent damage, during extensive culture passages ("replicative senescence").
Primary cultured cells undergo replicative senescence, which is characterized by telomere shortening, genomic damage, epigenomic damage, and activation of tumor suppressors [1].