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We found that Plasmodium products continuously accumulate in the bone marrow niche which turns the bone noticeably black in colour, and results in it being 'eaten-up' by bone resorbing cells known as osteoclasts, eventually disrupting bone homeostasis," first author of the study Michelle Lee from Osaka University said.
Current therapeutics target bone resorbing osteoclasts, but these are associated with severe side effects.
Mollugin efficiently suppressed RANKL-induced osteoclast differentiation of bone marrow macrophages (BMMs) and bone resorbing activity of mature osteoclasts by inhibiting RANKL-induced c-Fos and NFATc1 expression.
If the linear resorption patterns found in this study are indicative of resource allocation trends, we propose two hypotheses as to why the middle juvenile most often remains un-resorbed: (1) because the middle individual is fed by the most vessels, it is simply easiest for the chimera to concentrate resources by converging into the center; or (2) by resorbing into the central individual, the chimera is potentially providing itself a buffer zone of empty space for future growth, reducing immediate contact with nearby individuals.
Cathepsin K, a cysteine protease enzyme, is the most abundantly synthesized protein of the resorbing osteoclast and plays a role in the degradation of organic matrix in the bone, noted Dr.
Cathepsin K, a cysteine protease enzyme, is the most abundantly synthesized protein of the resorbing osteoclast, and plays an important role in the degradation of the organic matrix of bone.
Still other females were resorbing eggs, as the fish do when they're stressed or can't spawn.