It is characterized by lysosomal acid sphingomyelinase (ASM) deficiency causing accumulation of cholesterol and sphingomyelin in various organs, intercellular space, central nervous system and especially in reticuloendothelial
system cells (1).
The underlying mechanism is thought to be the reduced lifespan of platelets due to antibodies-mediated accelerated destruction by the reticuloendothelial
system and abnormal production by bone marrow.2,3 Previously, it was believed that increased platelet destruction at a rate exceeding production by a compensating bone marrow is solely responsible for ITP, but recent advancements proved that platelet production is also decreased in many patients with ITP.1,4
They are destroyed in the spleen and other reticuloendothelial
(1,2) After entering the body, Brucella becomes sequestered within the cells of the reticuloendothelial
The lower Hb, PCV and TEC are important indicator of anaemia, which could be attributed to immune mediated destruction of parasitised and non-parasitised erythrocytes due to increased level of activated complement products and removal of destroyed cells by bovine reticuloendothelial
system (De et al., 2012).
It has been postulated that increased infection in cirrhotic patients may be attributable to a defective reticuloendothelial
system leading to increased survival of bacteria in the bloodstream.2 This patient was admitted with hepatosplenomegaly, jaundice and ascites which suggests that maybe he was syndromic or suffering from primary immunodeficiency.
Varicella Zoster virus (VZV), the causative agent of chickenpox, proliferates in the respiratory mucosa and, then, enters into the reticuloendothelial
system through blood and the lymphatic system, ultimately resulting in vesicular skin rash.
Autoimmune hemolytic anemia (AIHA) is a disease that is characterized with the antibody production against erythrocyte antigens and degradation of the antibody coated erythrocytes by the reticuloendothelial
Two of the greatest challenges are to escape capture by the reticuloendothelial
system (RES) and to target the tumor tissue (7).
Visceral leishmaniasis (VL) is a protozoal disease that infects the reticuloendothelial
system and can cause death, if left untreated.
Lymphomas are a group of neoplasms of the lymphatic and reticuloendothelial
There are many theories about their formation but the most accepted one is that they are formed as a result of metaplastic changes taking place in reticuloendothelial
cells of blood vessels upon stimulations such as necrosis, infection and stress (5).