reverse transcriptase


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Related to reverse transcriptase: reverse transcription, Reverse transcriptase inhibitors

reverse transcriptase

n.
A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus.

reverse transcriptase

(trænˈskrɪpteɪz)
n
(Biochemistry) an enzyme present in retroviruses that copies RNA into DNA, thus reversing the usual flow of genetic information in which DNA is copied into RNA

reverse′ tran•scrip′tase

(trænˈskrɪp teɪs, -teɪz)
n.
a retrovirus enzyme that synthesizes DNA from viral RNA, the reverse of the usual DNA-to-RNA replication: used in genetic engineering.
[1970–75]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.reverse transcriptase - a polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses
polymerase - an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA
References in periodicals archive ?
The researchers found telomerase reverse transcriptase gene mutations in three of the 292 smokers with emphysema, a disease in which the air sacs in the lungs are gradually damaged, making the person increasingly more short of breath.
WarmStart RTx is an in silico-engineered thermostable reverse transcriptase, designed by our researchers for speed, sensitivity and inhibitor resistance in reverse transcription loop-mediated isothermal amplification (RT-LAMP), RT-PCR, and other applications where the detection of low-quantities of target RNA from complex sample matrices is critical.
About 10 years ago, biochemical studies in several laboratories established that AZT-resistant HIV-1 reverse transcriptase uses adenosine triphosphate, or ATP, which moves energy around inside the cell, to remove the AZT.
Intrapartum and neonatal single-dose nevirapine are commonly used and essential in the prevention of mother-to-child transmission of HIV in resource-poor settings, but may induce resistance to other non-nucleoside reverse transcriptase inhibitors.
They recorded the incidence of myocardial infarction during the follow-up period and looked at the associations between myocardial infarction and exposure to protease inhibitors or non-nucleoside reverse transcriptase inhibitors.
Viral enzymes reverse transcriptase, protease, and integrase are transcribed from which of the following genes?
Reverset is a nucleoside analog reverse transcriptase inhibitor that is being developed as a once-daily oral HIV therapy by Incyte Corporation and Pharmasset, Inc.
Even though other studies showed that elevations in triglyceride and cholesterol and body shape changes were also seen with the other classes of drugs and not just the protease inhibitors, the field had moved to using a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen as part of first-line therapy.
NcRTIs -- Nucleotide-competitive Reverse Transcriptase Inhibitors
The randomized study of 122 patients with HIV added a protease inhibitor to a standard regimen of two nucleoside reverse transcriptase inhibitors and one nonnucleoside reverse transcriptase inhibitor for 62 patients who continued the induction regimen for 24-32 weeks in order to lower viral load to less than 50 copies/mL.
In another type of test, RNA isolated from exposed cells was converted to cDNA and amplified by QRT-PCR (quantitative real-time reverse transcriptase polymerase chain reaction) to quantify gene expression.
Another new anti-HIV drug in the non-nucleoside reverse transcriptase inhibitor (NNRTI) class that has shown promise ("Full Pipeline: Success of experimental AIDS drugs offers promise of future therapies," SN: 2/22/03, p.

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