reverse transcriptase inhibitor


Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.
Related to reverse transcriptase inhibitor: NNRTI, NRTI

reverse transcriptase inhibitor

n. Abbr. RTI
Any of various antiviral compounds that interfere with the activity of the enzyme reverse transcriptase, which is found especially in retroviruses such as HIV. These compounds are divided into two classes: those that are nucleoside analogs (nucleoside reverse transcriptase inhibitors) and those that are not nucleoside analogs (non-nucleoside reverse transcriptase inhibitors).
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
NNRTI, non-nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; binds directly to reverse transcriptase and prevents RNA conversion to DNA; often used in combination with other drugs
NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
References in periodicals archive ?
The team tested six different HIV reverse transcriptase inhibitors to see if they could block L1 activity and the interferon response.
There are no clinically significant pharmacokinetic interactions between nucleoside reverse transcriptase inhibitors (NRTIs) and rifampicin-based TB treatment.
nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), RNA polymerase inhibitors, integrase inhibitors.
Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog reverse transcriptase inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
These are called reverse transcriptase inhibitors, and there are two subclasses within this group--nucleoside reverse transcriptase inhibitors (NRTI) and non-nucleoside reverse transcriptase inhibitors (NNRTI).
Agouron acquired the rights to develop and commercialize a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) from Shionogi & Co.
Bone densities were retested after 48 weeks of combination HIV therapy with a nonnucleoside reverse transcriptase inhibitor (NNRTI) and nucleoside reverse transcriptase inhibitors (NRTIs), or an NNRTI and a boosted protease inhibitor, or two NRTIs and a boosted protease inhibitor.
Treatment typically consists of three anti-HIV drugs, with one either a potent protease inhibitor, first available in December 1995; or a nonnucleoside reverse transcriptase inhibitor, first available in June 1996.
* The FDA approves the nucleoside reverse transcriptase inhibitor (NRTI), lamivudine (Epivir, 3TC), by accelerated approval.
* The combination of Viread and either Epivir (3TC) or Emtriva (FTC) is now recommended as a 2-nuke backbone for regimens based on either a non-nucleoside reverse transcriptase inhibitor ("non-nuke") or a protease inhibitor.
SPD754, a nucleoside reverse transcriptase inhibitor (NRTi), has already successfully completed a Phase IIa trial in 63 HIV-infected patients.
Another new anti-HIV drug in the non-nucleoside reverse transcriptase inhibitor (NNRTI) class that has shown promise ("Full Pipeline: Success of experimental AIDS drugs offers promise of future therapies," SN: 2/22/03, p.

Full browser ?