reverse transcriptase inhibitor


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Related to reverse transcriptase inhibitor: NNRTI, NRTI

reverse transcriptase inhibitor

n. Abbr. RTI
Any of various antiviral compounds that interfere with the activity of the enzyme reverse transcriptase, which is found especially in retroviruses such as HIV. These compounds are divided into two classes: those that are nucleoside analogs (nucleoside reverse transcriptase inhibitors) and those that are not nucleoside analogs (non-nucleoside reverse transcriptase inhibitors).
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
NNRTI, non-nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; binds directly to reverse transcriptase and prevents RNA conversion to DNA; often used in combination with other drugs
NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
References in periodicals archive ?
Rifampicin, a key component of TB treatment, is a potent inducer of drug metabolism and decreases plasma concentrations of many co-administered drugs, including non-nucleoside reverse transcriptase inhibitors, protease inhibitors and integrase inhibitors.
Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog reverse transcriptase inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
Many people did not achieve durable virologic benefits from these drugs, mainly because they had previously taken and developed resistance to the nucleoside analog reverse transcriptase inhibitors (NRTIs).
The most common combinations of two nucleoside reverse transcriptase inhibitors were didanosine plus stavudine (52% of patients) and zidovudine plus lamivudine (42%).
A novel nucleoside reverse transcriptase inhibitor candidate - EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) - has shown antiviral activity toward highly resistant HIV strains.
Currently reverse transcriptase inhibitors represent over 50% of the global sales of HIV drugs which in 2004 was in excess of US$6 billion.
NcRTIs -- Nucleotide-competitive Reverse Transcriptase Inhibitors
High AST also was predictive of severe hepatotoxicity in the first 6 months of therapy among patients using a non-nucleoside reverse transcriptase inhibitor (OR 2.
Additionally, the company announced plans to initiate a Phase II study for a proprietary investigational next generation non-nucleoside reverse transcriptase inhibitor, MK-1439.
New precautions have been added to the labeling for Viramune, a non-nucleoside reverse transcriptase inhibitor (NNRTI or "non-nuke").
The four new anti-HIV drugs that came out in 2003 are Fuzeon, part of a new class of drugs called entry inhibitors or fusion inhibitors; the protease inhibitors Reyataz and Lexiva; and the reverse transcriptase inhibitor Emtriva.
ATRIPLA contains 600 mg of efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate, both nucleoside reverse transcriptase inhibitors (NRTIs).

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