AXS-07 consists of MoSEIC meloxicam and rizatriptan
. The distinct mechanism of action and rapid absorption of MoSEIC meloxicam, combined with the known efficacy of rizatriptan
, are designed to enable rapid, superior, and consistent relief of migraine pain, with lower symptom recurrence, as compared to currently available therapies.
Table 1 Medications associated with serotonin syndrome Class Medication(s) Antidepressants Selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants Monoamine oxidase inhibitors Trazodone Mirtazapine Triptans Almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan
, sumatriptan, zolmitriptan Anxiolytics Buspirone Antiemetics Ondansetron, granisetron, metoclopramide Herbal supplements St.
, the most well studied triptan in the pediatric population, is approved for use in children as young as 6 years (49); the pediatric dosage is 5 mg/d for patients weighing 20 to 39 kg and 10 mg/d for patients weighing more than 40 kg (same as the adult dosage).
For the rizatriptan
(Maxalt, Maxalt-MLT) tablet, animal data suggest low risk.
in migraineurs with unilateral cranial autonomic symptoms.
Afkhami, "Magnetic solid phase extraction of rizatriptan
in human urine samples prior to its spectrofluorimetric determination," Sensors and Actuators B: Chemical, vol.
Wagh, "Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan
benzoate," Carbohydrate Polymers, vol.
Vinay, "Sensitive and selective spectrophotometric assay of rizatriptan
benzoate in pharmaceuticals using three sulphonphthalein dyes," Arabian Journal of Chemistry, vol.
Eghbal, "Triazole rizatriptan
induces liver toxicity through lysosomal/mitochondrial dysfunction," Drug Research, vol.
In addition to these, there are a number of 1,2,4-triazole-containing drugs on the market like letrozole, vorozole and anastrozole (antitumor) , ribavirin, viramidine (antiviral) , rizatriptan
(antimigrane) , fluconazole, itraconazole, terconazole (antifungal) , loreclezole (sedative and anticonvulsant) , hexaconazole, myclobutanil, triadimefon and tebuconazole (fungicide) .
Rizaport is a proprietary oral thin film formulation of rizatriptan
benzoate that rapidly dissolves and releases its active ingredient in the mouth, resulting in efficient absorption of the drug.
Two randomized and controlled studies with triptans-zolmitriptan versus placebo during VM attacks and rizatriptan
versus placebo in migraine patients, with or without dizziness in provoked motion sickness-produced inconclusive, because of the large confidence intervals and a small number of patients enrolled [93-95].