University of Hong Kong (Hong Kong, China) has patented a method for inhibiting Hepatitis B virus (HBV) replication by RNA
The discovery and description of RNA
silencing less than a decade ago has spawned a flood of research, revolutionizing the practice of functional genomics and leading to intensive exploration of its potential application to treat numerous diseases.
Membraneless assemblies of positively- and negatively-charged molecules can bring together RNA
molecules in dense liquid droplets, allowing the RNAs
to participate in fundamental chemical reactions.
Subsequently, the researchers devised a new method for extracting small RNAs
from Prunus and monitored their suitability for further analysis by testing the high-molecular weight (HMW) RNA
in the sample using automated CE.
A similar level of fluorescence intensity was detected in the cDNA prepared from muscle and hepatopancreas RNAs
isolated using method III (Fig.
At least three classes of sRNAs derived from regions mapping around the 5; termini of genes have been described: transcription initiation RNAs
(tiRNAs) , transcription start site-associated RNAs
(TSSa-RNAs) [6-8], and promoter-associated small RNAs
(PASRs) [9, 10].
"A significant amount of research is being invested in understanding the complex nature of how various chromatin-associated RNAs
impact gene expression and epigenetic regulation," said Christophe Couturier, senior vice president and head of the EMD Millipore Bioscience Business Area.
20 August 2014 - US recombinant enzymes and related reagents maker New England Biolabs, or NEB, said yesterday it had exclusively licensed the rights to US Genomic Health Inc's (NASDAQ:GHDX) technology for depletion of abundant RNAs
, which is used to conduct sensitive RNA-seq experiments at a reduced cost.
Depending on the duration of preservation and temperature, the TriPure reagent was able to produce RNAs
with different integrities (figures 4 and 5).
The researchers also discovered a signature of changes in expression of other genes that accompanies expression of the repeat-containing RNAs
can do important work without making proteins, the definition of a gene needs to be expanded, says Leonard Lipovich, a geneticist at Wayne State University in Detroit.
In a major cancer-research breakthrough, researchers at McGill have discovered that a small segment of a protein that interacts with RNA
can control the normal expression of genes--including those that are active in cancer.