rofecoxib


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Related to rofecoxib: Etoricoxib
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Noun1.rofecoxib - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
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The drugs evaluated by researchers were COX-2 inhibitors, which include celecoxib, rofecoxib, diclofenac, meloxicam, and etodolac, among others.
These include rofecoxib (Vioxx), valdecoxib (Bextra), and sibutramine (Meridia).
Rofecoxib (Merck) was introduced in 1999 as an effective, safer alternative to non-steroidal anti-inflammatory drugs for treating pain associated with osteo-arthritis.
They included 31 trials and 116,429 patients taking seven different drugs (naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib, rofecoxib, lumiracoxib) or placebo to provide a more reliable estimate of the cardiovascular risks of these drugs than previous studies.
A significant increase in risk was seen after 1 week of treatment with Ibuprofen, in the first week of treatment with rofecoxib (which has been withdrawn from the market), and after 14-30 days with celecoxib.
A significant increase in risk was seen after 1 week of treatment with, ibuprofen, in the first week of treatment with rofecoxib (which has been withdrawn from the market), and after 14-30 days with celecoxib.
In the latest analysis, naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib, rofecoxib and lumiracoxib were scrutinised.
In the latest analysis, the medicines naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib, rofecoxib and lumiracoxib were scrutinised.
Compared with placebo, rofecoxib was associated with the highest risk of myocardial infarction (rate ratio 2.
and consulting fees from plaintiffs' attorneys in litigation involving rofecoxib and zoledronic acid and from insurers regarding rofecoxib and hormone replacement therapy.
Guest Authorship and Ghostwriting in Publications Related to Rofecoxib: A Case Study of Industry Documents from Rofecoxib Litigation, JAMA (Apr.
Both valdecoxib and rofecoxib provide similar benefits.