The uniform vote to keep celecoxib on the market and the split votes regarding rofecoxib
and valdecoxib reflected the clear hazard seen with those two drugs.
Past studies indicated that aspirin and related anti-inflammatory drugs, which broadly inhibit cyclooxygenase enzymes, and drugs such as celecoxib (Celebrex) and rofecoxib
(Vioxx), which selectively block COX-2 production, can prevent or stop certain cancers from growing.
But Vioxx Acute, made by Merck Sharp & Dohme Limited, contains rofecoxib
which allows the stomach enzyme to keep working.
has announced that it will pay $4.85 billion into a fund to settle claims that its cyclooxygenase-2 inhibitor rofecoxib
(Vioxx) was responsible for causing myocardial infarction and stroke in patients who took the drug for pain.
In the wake of the withdrawal of rofecoxib
and the addition of a black box warning for antidepressants, the Food and Drug Administration has announced a plan aimed at strengthening its safety program for drugs.
(We were covering for another practice.) Her medications prior to admission were metformin, omeprazole, amitriptyline, and metoprolol, to which rofecoxib
had recently been added.
HONOLULU -- Rofecoxib
, a selective cyclooxygenase-2 inhibitor, significantly reduced the frequency of perimenstrual migraine headaches in a small, open-label trial.
Newer prescription drugs, celecoxib and rofecoxib
, target COX-2 only.
) is the the first of a new generation of NSAIDs which also protect the lining of the stomach and intestines from everyday damage.
Previously, the congressional watchdog agency reviewed the regulatory history of the drug Vioxx (rofecoxib
), which was pulled from the market in 2004 after being linked to heart attacks and strokes.
A federal jury has rejected the lawsuit of Tennessee resident Anthony Dedrick, who claimed that his 2003 heart attack was caused by Vioxx (rofecoxib
The COX-2 inhibitors rofecoxib
(Vioxx) and celecoxib (Celebrex) have been shown to provide equal pain relief compared with naproxen for patients with osteoarthritis.