Genetic diversity and classification of the outer capsid glycoprotein VP7 of porcine group B rotaviruses
. Arch Virol.
To guard against the other three strains, the scientists let the monkey virus exchange a gene with each of the target human rotaviruses
. This gene encodes a cell surface protein recognizable to the human immune system, which then makes antibodies to fight the virus.
We and others (3,4,6) have characterized the secretor and Lewis phenotypes related to infection by rotaviruses
. The interaction between rotavirus particles and HBGAs might constitute the first step in the attachment to the cell before internalization of the virus particle, after binding with integrins (4,5).
. In: Fields BN, Knipe DM, Howley PM, et al, eds.
He added: "This reveals that there is a common chink in the armour of these rotaviruses
. This discovery is the first step in designing a broad-spectrum drug able to exploit this weakness to combat many types of human and animal rotaviruses
Marin, "Human, porcine and bovine rotaviruses
in Slovenia: evidence ofinterspecies transmission and genome reassortment," Journal of General Virology, vol.
(9.) Ceyhan M, Kanra G, Yeniay I, Ciliv G, Vesikari T Rotaviruses
in infants with diarrhea studied by viral RNA electrophoresis in Ankara, Turkey.
are the major cause of paediatric diarrhoeal disease morbidity and mortality.
occur widely among humans and many animal species throughout the world, and are important causes of gastroenteritis.
These measures also will assist in assessing vaccine program effectiveness and the potential emergence of novel or unusual rotaviruses
A group of viruses called rotaviruses
cause serious diarrhea in young children, but often are difficult to identify.
circulating in the United States belong to a limited number of strains, routinely characterized by serologic or genetic identification of the outer capsid protein antigens viral protein (VP) 7, which defines G types, and VP4, which defines P types (6,7).