Salvia divinorum and Salvinorin
A: an update on pharmacology and analytical methodology.
Localization of salvinorin
A and related compounds in glandular trichomes of the psychoactive sage Salvia divinorum.
The active ingredient, salvinorin
A, is typically measured by liquid chromatography at many reference laboratories.
21) The psychoactive agent in Salvia is salvinorin
A, a diterpene and selective kappa-opioid receptor agonist, which produces psychomimetc effects on ingestion of teas brewed from leaves, resembling the adverse effects caused by serotonergic agonists, selective serotonin reuptake inhibitors, or n-methyl-d-aspartate glutamate (NMDA) antagonists.
and colleagues looked at how the drug JDTic deactivates a kappa opioid receptor, which is turned on by the hallucinogen salvinorin
Possessing, with the intent to distribute, intoxicating substances, to include, but not limited to, Salvia Divinorum, Salvinorin
A, or the intoxicants "spice," "Ivory Wave," or any derivative thereof (see enclosure for a non-inclusive list of prohibited substances and derivatives);
At the molecular level, drugs like salvinorin
A (the active ingredient of the hallucinogenic plant Salvia divinorum) work by activating specific proteins, known as receptors, in the brain and body.
Salvia is an herb that contains the active ingredient salvinorin
Dopamine D2 (High) receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin
A, and modafinil.
The researchers conducted a double-blind trial in four psychologically and physically healthy hallucinogen-using adults, giving them 16 ascending doses of salvinorin
A and 4 intermixed placebo doses over 20 sessions and several weeks.
In what is believed to be the first controlled human study of the effects of salvinorin
A, the active ingredient in Salvia divinorum, a controversial new hallucinogen featured widely on You Tube and other internet sites, Johns Hopkins researchers report that the effects are surprisingly strong, brief, and intensely disorienting, but without apparent short-term adverse effects in healthy people.
NewsScan #64 includes summaries of eight NIDA-funded scientific studies on a variety of topics, including brain imaging of sensation-seeking individuals, the role of glial cells in morphinea[euro](tm)s effects in the brain, awareness deficits among marijuana abusers, the effects of two drugs on reducing opioid withdrawal symptoms, the behavioral effects of salvinorin
A in non-human primates, drug abuse risk factors for traumatic brain injury survivors, use of marijuana among those with a subtype of testicular cancer, and environmental cues associated with nicotine.