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Related to saquinavir: ritonavir, nelfinavir, Saquinavir mesylate


A protease-inhibiting drug given in the form of its mesylate, used usually in combination with other drugs to suppress the replication of HIV.

[saquin- (perhaps alteration of (i)soquin(oline) : iso- + quinoline) + a(nti)vir(al).]
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Noun1.saquinavir - a weak protease inhibitor (trade name Invirase) used in treating HIV
protease inhibitor, PI - an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs


n saquinavir m
References in periodicals archive ?
2004) Association of the CYP3A5 A6986G (CYP3A5*3) polymorphism with saquinavir pharmacokinetics.
Description of the order: the chemical name | dose | unit | the number of units in the package - the number of packages: Saquinavir mesylate | 500 mg | tablet | 120 - Number of packages: 550.
The PIs used were nelfinavir until 2007, saquinavir, fosamprenavir, lopinavir, atazanavir and, from 2009, darunavir.
Some examples of strong CYP3A4 inhibitors are ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelflnavir, indinavir, boceprevir, telaprevir, telithromycin, and conivaptan.
The company offers protease inhibitors such as ritonavir, darunavir, saquinavir, amprenavir, lopinavir, atazanavir, indinavir and tipranavir.
I was initially FEARS Kellan, No vote will be treated with the drugs saquinavir, epivir and AZT plus a prophylactic antibiotic septrin to ward off pneumonia.
The AIDS "cocktail" was introduced in 1992 (the same year David Wojnarowicz died), followed in 1995 with the development of the protease inhibitor Saquinavir.
Brundage and colleagues from the ACTG 359 pharmacology group reported on the difference in saquinavir exposure between men and women enrolled in this salvage trial.
One study showed that saquinavir, commonly used in HAART regimens, results in decreased sperm motility in vitro and negatively affects mechanisms that are essential to fertilization of an oocyte such as the acrosome reaction (50).
La toxicidad hepatica secundaria a la terapia antirretroviral esta bien descrita, sobre todo, los casos secundarios al uso de nevirapina y a algunos inhibidores de las proteinas como ritonavir, saquinavir e indinavir (10).
In order to overcome the effect of rifampicin on boosted lopinavir or saquinavir, the dose of ritonavir can be increased (400 mg of ritonavir 12-hourly in combination with 400 mg of lopinavir or saquinavir 12-hourly in adults).
Ante esta situacion, ademas de las medidas preventivas como la utilizacion del condon y la transfusion de sangre proviente de donadores sanos, se han realizado avances en el tratamiento de la enfermedad, gracias a la creacion de medicamentos antirtrovirales, como zidouvidna, didanosina, zalcibatina, estavudina, lamivudina, abacir, zialgen, nevirapina, delavirdina, efavirenz, indinavir, ritonavir, saquinavir y nelfinavir.