channel on the endoplasmic reticulum (or sarcoplasmic
reticulum in muscle cells).
The faster pH decline caused denaturation of sarcoplasmic
and myofibrillar proteins, resulting in reduced water holding capacity .
The RYR1 gene encodes the skeletal muscle ryanodine receptor, which serves as a calcium release channel of the sarcoplasmic
reticulum as well as a bridging structure connecting the sarcoplasmic
reticulum and transverse tubule.
Under normal conditions, GPBB can tightly integrate with the sarcoplasmic
reticulum in myocardial cells in the form of GPBB glycogen complex, which cannot be broken down easily.
2015) can lead to the absence of dystrophin in the sarcoplasmic
membrane of the muscle cells and cause its rupture, calcium influx and subsequent activation of endogenous protease with activation of inflammatory cascade, and consequent necrosis and replacement of muscle tissue by adipose and fibrous tissue (DILAYLA & ABREU, 2015).
Glycogen phosphorylase (GP) is bound to glycogen in sarcoplasmic
reticulum and catalyzes the first step of glycogenolysis after activation, which involves the separation of glucose-1-phosphate from glycogen.
Shigenobu, Possible Action of Cyclopiazonic Acid on Myocardial Sarcoplasmic
Reticulum: Inotropic Effects on Neonatal and Adult Rat Heart, J.
Muscle-type MM creatine kinase is specifically boundto sarcoplasmic
reticulum and can support Ca2+ uptake and regulate local ATP/ADP ratios.
In particular, alcoholic myopathy is characterized by decreased protein synthesis (Steiner and Lang 2015) of both myofibrillar and sarcoplasmic
proteins (Preedy and Peters 1988).
It depends on the efficient release of calcium from sarcoplasmic
reticulum which was not affected in fast muscles.
Caffeine may also affect performance via both central and peripheral mechanisms by altering pain and effort perception (13), calcium kinetics in the sarcoplasmic
reticulum (1,35), and sodium/potassium ATPase pump activity (29) among other potential mechanisms (18).
Jones (1996) has proposed that the primary mechanism responsible for LFF is a decrease in calcium release from sarcoplasmic
reticulum that affects E-C coupling process.