Chronic heart failure (HF) is a progressive, multifactorial, and debilitating disease that is often characterized by the impairment of systolic function and the loss of calcium homeostasis due to insufficient reuptake of calcium ions back into sarcoplasmic reticulum
(SR) using Ca [sup]2+-ATPase and/or insufficient inflow of calcium ions into myocytes through using Na [sup]+/Ca [sup]2+ exchanger.
It is believed that prolonged LFF is the result of uncoupling of E-C process that leads to a reduction in rate of calcium release from the sarcoplasmic reticulum
per action potential (Jones, 1996).
2+] uptake into the sarcoplasmic reticulum
and activation of [Ca.
Analysis by electronic microscopy showed that the patient-specific cardiomyocytes had immature phenotype, less organized myofibrils, enlarged cisterns of sarcoplasmic reticulum
, and reduced number of caveolae .
2+]-ATPase of cardiac sarcoplasmic reticulum
," Molecular and Cellular Biochemistry, vol.
Delineation of three different thyroid hormone-response elements in promoter of rat sarcoplasmic reticulum
Subsequent to the calcium release into the myoplasm, the sarcoendoplasmic reticulum ATPase (SERCA) works to sequester calcium back into the sarcoplasmic reticulum
, again via ATP dependent enzymatic activity.
Thermal Acclimation of Skeletal Muscle Sarcoplasmic Reticulum
Ca2+ATPase (SERCA) in Bluefin Tuna, Thunnus orientalis.
Structure and function of the calcium pump protein of sarcoplasmic reticulum
9) This potentiates the release of calcium ions from the sarcoplasmic reticulum
into the sarcoplasm.
This could be explained by the inotropic effect of taurine that, as previously demonstrated, stimulates the release of calcium from the sarcoplasmic reticulum
," he added.
Inhibition of rapid Ca-release from isolated skeletal and cardiac sarcoplasmic reticulum