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A recombinant form of granulocyte-macrophage colony-stimulating factor, used as a drug to increase white blood cells following certain forms of chemotherapy and in patients undergoing bone marrow transplantation.

[sar-, of unknown origin + -gramostim (from gra(nulocyte) m(acrophage) (c)o(lony) stim(ulating factor)).]
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12, 34-37) This involves in-depth immune profile blood testing and when indicated, precise administration of expensive drugs like interleukin-2, (12,38-46) filgrastim (Neupogen[R]), (47,48) pegfilgrastim (Neulasta[R]), (49-58) and/or sargramostim (Leukine[R]).
Your doctor should also prescribe medications such as filgrastim (Neupogen), pegfilgrastim (Neulasta) or sargramostim (Leukine) between chemotherapy cycles to quickly restore reduced white blood cell counts to normal levels to help prevent infection.
Patients with febrile neutropenia given prophylactic filgrastim or sargramostim should continue with G-CSF therapy; however, as pegfilgrastim is long acting patients given prophylactic pegfilgrastim should not be treated with additional G-CSF (66).
Also, results from open-label studies and one randomized, placebo-controlled study suggest that treatment of CD patients with sargramostim (Leukine[R], Berlex, New Jersey), a yeast-derived recombinant human granulocyte-macrophage colony-stimulating factor, may attenuate severity of the disease, promote overall improvement and, in some cases, may induce disease remission (11-14).
Comparison of sargramostim and filgrastim in the treatment of chemotherapy-induced neutropenia.
La Sociedad Americana de Oncologia Clinica establece niveles de evidencia I grado A y I grado C para la administracion primaria de filgrastim y sargramostim, respectivamente, con las siguientes indicaciones: pacientes con cultivos positivos persistentes a pesar del tratamiento, neutropenia que persiste por diez o mas dias a pesar de estar recibiendo antibioticos, pacientes en mal estado general cuando comienza la fiebre, pacientes con complicaciones durante el tratamiento, como neumonia, hipotension, celulitis grave, micosis sistemica y disfuncion multiorganica secundaria a sepsis.
Thousand Oaks, CA), and granulocyte -macrophage colony-stimulating factors, such as sargramostim (Leukine[R], Berlex Laboratories, Montville, NJ).
HONOLULU -- Sargramostim shows considerable promise as a novel treatment for Crohn's disease, Dr.
Filigastrim (Neupogen[R]) and sargramostim (Leukine[R]) are used to enhance the WBC count (Pagana & Pagana, 2002).
COPENHAGEN -- Daily treatment with sargramostim led to significantly improved quality of life in patients with moderate to severe Crohn's disease in a study with 124 patients.
To read the complete abstract and research on GM-CSF Sargramostim please visit: www.
Myeloid growth factors recommended in the guidelines are filgrastim (Neupogen(R), Amgen), sargramostim (Leukine(R), Berlex), and pegfilgrastim (Neulasta(R), Amgen).