We took into consideration for differential diagnosis several scleroderma-like disorders: eosinophilic fasciitis, localized and systemic sclerosis, nephrogenic systemic fibrosis, scleromyxedema, scleredema
and eosinophilia myalgia syndrome.
They often have antibodies to Scl-70.2 SSc mimics many other skin conditions like generalized morphea, scleromyxedema, scleredema
of Buschke, primary systemic amyloidosis, chronic graft-versus-host disease, eosinophilic fasciitis etc.3 The criteria for diagnosis of systemic sclerosis have been established by the subcommittee for scleroderma criteria of American Rheumatism Association (now called the American College of Rheumatology).4
diabeticorum (SD) is a rare condition of unknown pathogenesis and is characterized by nonpitting thickening and induration of the skin [7, 8].
There are other skin conditions (subcutaneous fat necrosis of newborn, scleredema
) presenting similarly as hardening of skin which may cause diagnostic difficulties .
Xerosis Purpura Pruritus Gynaecomastia Pigmentary Changes Uraemic Frost Bullous Dermatoses Oral Mucosal Changes Metastatic Calcification Scleredema
adultorum perforating Dermatoses of Buschke Nail Changes
Antibiotics were routinely employed to prevent infection, and warm-keeping measures were taken to prevent the occurrence of neonatal scleredema
. In addition, the urine was monitored, and peritoneal dialysis should be timely applied once renal insufficiency was detected.
KEY WORDS: AY2-microglobulin Ligustrazine Neonatal scleredema
Renal brush border membrane enzyme Renal injury.
is a rare and self-limiting skin condition affecting primarily preterm neonates in the first week of life.
Neonates were categorized as stable (Group A) and Unstable (Group B) depending upon the absence or presence of illnesses like birth asphyxia, neonatal sepsis, meningitis, respiratory distress and physiological derangements like vital signs abnormalities, hypoxia, hypoglycemia, shock, deep jaundice and scleredema
. Only clinical criteria for the diagnoses of these illnesses and their categorization as stable 13 or unstable were used .
(7), (10) A negative ANA is again more meaningful as its negative LR is 0.27 for scleroderma. A negative ANA test might point to other fibrosing illnesses, such as linear or local scleroderma, eosinophilic fasciitis, and scleredema
tends to target the upper body without affecting the lower extremities.
of Buschke or scleredema
adultorum is a rare primary cutaneous fibromucinosis of unknown etiology that is characterized by extensive woody, non-pitting induration of skin throughout the body, with systemic involvement being rather uncommon.