sclerodermatous


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scle·ro·der·ma·tous

 (sklîr′ə-dûr′mə-təs)
adj.
1. Of, relating to, or affected by scleroderma.
2. Zoology Having an outer covering of hard plates or bony scales.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

sclerodermatous

(ˌsklɪərəʊˈdɜːmətəs)
adj
1. (Zoology) (of animals) possessing a hard external covering of scales or plates
2. (Pathology) of or relating to scleroderma
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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The single major criterion is presence of sclerodermatous involvement proximal to the digits, affecting limbs, face, neck, or trunk usually in a bilateral and symmetrical pattern.; the minor criteria are sclerodactyly, digital pitted scars or tissue loss of volar pads of fingertips, and bibasilar pulmonary fibrosis.4 The diagnosis is based on presence of either the major criterion or at least two of minor criteria.
Conclusions: Data demonstrate ATYR1923 is efficacious in a murine model of sclerodermatous chronic graft versus host disease when administered weekly at only 0.4 mg/kg.
Min, "Mesenchymal stem cells (MSCs) attenuate cutaneous sclerodermatous graft-versus-host disease (Scl-GVHD) through inhibition of immune cell infiltration in a mouse model," The Journal of Investigative Dermatology, vol.
Aside from the acute gastric GVHD and mild transaminase elevation consistent with liver GVHD discussed above, the course was complicated only by ongoing and difficult-to-control diffuse chronic sclerodermatous GVHD of the skin requiring several courses of immunosuppressive therapy.
Jin et al., "Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease," Blood, vol.
Progeric children are normal at birth and within the first year of life develop severe growth deficiency with sclerodermatous skin changes.
The affected demonstrates a characteristic features by displaying delayed growth, osteoporosis, cardiovascular ailments, alopecia, pinched nose, and sclerodermatous skin [12,13].
Gilliam, "Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation," Journal of Immunology, vol.
sclerodermatous or "tumored" scales having tumour (scleroma)-like hardened skin scales
Radiation-induced fibrosis (RIF), radiation recall dermatitis, post-irradiation sclerodermatous panniculitis, and cancerous sclerosing recurrence are the main differential diagnoses.
If sclerodermatous changes are present, histology may reveal varying degree of collagen sclerosis resembling morphea.
Juvenile systemic sclerosis involves the skin, muscle, and visceral organs; therefore, the differential diagnosis should include other multiple-system organ diseases with skin involvement including juvenile dermatomyositis, mixed connective tissue disease, SLE, juvenile idiopathic arthritis, overlap syndrome, eosinophilic fasciitis, chronic graft versus host disease, nephrogenic systemic fibrosis, phenylketonuria with sclerodermatous skin lesions, and syndromes of premature aging.