Follow-up at 7 years also showed that 50 men had died from prostate cancer in the screening group
and 44 in the control group, a nonsignificant 13% difference.
During a mean follow-up of 4.8 years, there was no difference in the rates of cardiac events between patients in the screening group
and the 562 patients in the standard care control group, he said, noting that the cumulative rate of cardiac events for both groups was approximately 3%.
During a mean follow-up of 4.8 years, the cumulative rate of cardiac events for both groups was about 3% among patients in the screening group
and among the 562 patients in the standard care control group.
The screening group
underwent adenosine myocardial perfusion imaging (MPI), which detected inducible ischemia in 22%.
Nonfatal heart attacks occurred in 1.2% of the screening group
and in 1.8% of the control group.
In the screening group
, nonpolypoid lesions were more than twice as likely as polypoid lesions to contain neoplasms, whereas in the surveillance and symptomatic groups, they were more than three times as likely to contain neoplasms.
Detection of polyps measuring 6 mm or more occurred in 12.9% of the CT group and 13.4% of the therapeutic screening group
, and the prevalence and detection of advanced neoplasms also was similar, at 3.2% in the CT group and 3.4% in the therapeutic screening group
; the differences were not significant.
'As opposed to the high-grade tumors in our screening group
, the majority of high-grade tumors in the men who did not screen were already invasive when they were diagnosed.
As the coordinator of the ongoing European Randomized Study of Screening for Prostate Cancer, which has randomized more than 190,000 men to a screening group
or a control group, I hope the results will show a decrease in prostate cancer mortality that is acceptable in terms of damage caused by screening.
But those trials were complicated by two factors: Some women who are randomly invited to a screening group
decline to undergo mammography, and some women who are randomly assigned to a control group undergo mammography outside of the experiment.
In their 3-year study, 8,000 men aged 55 to 67 were randomly assigned each year to a screening group
; 35,973 other men served as controls.
None of those in the screening group
and 8% (nine patients) in the control group died of colorectal cancer.