Under investigation as a first-in-class topical androgen receptor inhibitor for treating acne, the clascoterone cream 1% is a topically delivered small molecule that penetrates the skin to reach the androgen receptors of the sebaceous gland
. The clascoterone inhibits lipid production from oil producing cells and reduces proinflammatory cytokines, mediators influenced by androgens, added the company.
In a new study, researchers from the Biotech Research & Innovation Centre (BRIC) and the Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), have gained new insight into how the skin, and in particular the sebaceous gland
, forms during development and how it is replenished throughout life.
Thinking about the basaloid cell population in sebaceoma as homologous to the proliferative basal layer of a normal sebaceous gland
should help observers accept and rationalize the presence of occasional mitoses in benign sebaceous lesions (Figure 3).
Usually, these particles do not get into the sebaceous glands
and appear to result in temporary improvement by wounding the infrainfundibular region of the sebaceous gland
It clearly targets the sebaceous gland
--decreasing sebocyte proliferation and suppressing sebum production --but an emerging body of research suggests that the drug also markedly affects dermal microbial colonization.
Further, successful elimination of Sebaceous Hyperplasia lesions substantiates the unique ability of NPS to penetrate into the dermis and target deeper cellular structures, such as the sebaceous gland
, without damaging the surrounding dermis.
Basal cell carcinoma (BCC) is the most frequent malignant eyelid tumor followed by squamous cell carcinoma (SCC), sebaceous gland
carcinoma and malignant melanoma.11
DHEAS, regulator of sebaceous gland
activity through its conversion to DHT and Testosterone in sebaceous gland
by potent enzymes.
Clinically, we made a diagnosis of Granulosis Rubra Nasi, Lymphangioma Circumscriptum, Nevus Comedonicus, and sebaceous gland
The sebaceous gland
tumors constituted the largest group (42.31% 11/26) cases followed by the sweat gland tumor (34.62%, 9/26) cases and hair follicle tumor (23.10%, 6/26) cases [Tables 1-3].
During a (http://onlinelibrary.wiley.com/doi/10.1002/ca.22571/full) 2015 study on facial eye wrinkles, doctors found that people with higher sebaceous gland
density, which are the glands in the skin that secrete oil, had shallower wrinkles than those who lacked in sebaceous glands
around their eyes.
The mass was histopathologically diagnosed as sebaceous gland