second-line


Also found in: Medical, Wikipedia.

sec·ond-line

 (sĕk′ənd-lĭn′)
adj.
1. Relating to or being a secondary stage of something: the body's second-line defense against infection.
2. Being a drug or therapy that is used to treat a condition or disease only after another drug or therapy has been used or considered.
3. Of or relating to second-line jazz.
References in periodicals archive ?
Few patients who are initiated on second-line treatment for type 2 diabetes mellitus show evidence of recommended use of first-line treatment with metformin, according to research published online Sept.
M2 EQUITYBITES-April 28, 2017-Bayer secures US FDA approval for Stivarga (regorafenib) tablets for second-line treatment of hepatocellular carcinoma
M2 PHARMA-April 28, 2017-Bayer secures US FDA approval for Stivarga (regorafenib) tablets for second-line treatment of hepatocellular carcinoma
This is largely because patients find it very hard to keep taking second-line drugs, which can be quite toxic, for prolonged periods of time.
4) Another potential second-line option is the use of an alternate TKI, such as sorafenib, which showed in the INTORSECT study to have comparable efficacy to temsirolimus.
As increasing numbers of patients are enrolled in treatment regimens, there is an increase in the number failing first-line ART and being switched to second-line ART.
A Medecins Sans Frontieres (MSF) report highlights how South Africa's current patent policy is stopping vital second-line HIV drugs from reaching those who can't afford them.
Extensively drug-resistant (XDR) tuberculosis (TB), a severe form of TB disease, is defined as TB that is resistant to at least rifampin and isoniazid (multidrug resistant [MDR]), as well as to any member of the quinolone family and at least 1 second-line anti-TB injectable drug: kanamycin, capreomycin, or amikacin (1,2).
They can be used alone or as a second-line therapy in combination with a wide range of anti-hypertensive drugs.
If, as usually happens, PZA and ETH are subsequently included in the second-line regimen to manage first-line failures or MDR-TB, the chances of developing further resistance to the other second-line drugs such as streptomycin (SM) are greatly magnified.
Truvada is a second-line anti-HIV drug in the nucleoside reverse transcriptase inhibitor (NRTI or "nuke") family and is used in combination with other medications to control HIV infection.
UNITAID, the financier of the Clinton Foundation, will provide more than $100 million to buy the second-line medicines from drug makers Cipla Ltd.