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Any of three subtypes of a protease located in cell membranes of the brain. In Alzheimer's disease, a secretase (designated beta) degrades amyloid precursor protein into beta-amyloid peptides that accumulate to form amyloid plaques.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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|Noun||1.||secretase - a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)|
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
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