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Related to secretin: cholecystokinin, CCK, secretin test


A polypeptide hormone that is produced in the duodenum, especially on contact with acid, and that inhibits gastric secretion of acid and stimulates secretion of bile, insulin, and pancreatic digestive enzymes.


(Physiology) a peptic hormone secreted by the mucosae of the duodenum and jejunum when food passes from the stomach
[C20: from secretion + -in]


(sɪˈkri tɪn)

a polypeptide hormone, produced in the small intestine, that activates the pancreas to secrete pancreatic juice.
[< German Secretin (1902); see secretion, -in1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.secretin - a gastrointestinal hormone that stimulates the secretion of water and bicarbonate from the pancreas and bile ducts whenever the stomach empties too much acid into the small intestine
gastrointestinal hormone, GI hormones - hormones that affect gastrointestinal functioning
References in periodicals archive ?
ETL is a member of the secretin family and belons to the epidermal growth factor-seven-transmembane subfamily.
In the present study, we designed a chimeric plasmid contains the pil[Q.sub.1138-2118] gene, which codes the immunologic domains of PilQ secretin (the C-terminal domain of the PilQ).
Recently, endoscopic pancreatic function test (ePFT) using secretin stimulation has made direct pancreatic function testing more accessible and time efficient allowing clinicians the opportunity to perform a functional assessment of pancreas with ease.
Smoking can also elevate the level of pancreatic zymogens in the blood stream after secretin stimulation [22].
Although direct methods employing pancreozymin and secretin have already been the gold standard, they are technically challenging, difficult to standardize, more time consuming, and discomforting to patients following simultaneous pancreas-kidney transplantation.
Secretin stimulation testing can also be used to differentiate patients with gastrinomas from other causes of hypergastrinemia, such as atrophic gastritis, renal failure, or vagotomy.
A study investigating MSCs and how they regulate macrophages found that by secreting secretin tumor cell line-1 (STC-1), MSCs can inhibit inflammasome activation in macrophages and prevent maturation and secretion of proinflammatory cytokines, including IL-1[beta] [119].
Grammatopoulos, "Focus on the splicing of Secretin GPCRs transmembrane-domain 7," Trends in Biochemical Sciences, vol.
Similar to operons in other enteric pathogens, ORFs for secretin protein PgaA protein (RWLH05284), a specific deacetylase PgaB (RWLH05283), N-acetylglucosaminyltransferase PgaC (RWLH0582) and polymerization protein PgaD (RWLH05281), which are involved in the synthesis and export of biofilm, were identified.
Severe chronic pancreatitis versus suspected pancreatic disease: dynamic MR cholangiopancreatography after secretin stimulation.
MRCP, in combination with the intravenous administration of secretin, has been successfully employed to improve characterization of pancreatic ductal anatomy, demonstrate ductal disruptions beyond an obstructed duct (unlike ERCP) and provide dynamic information about ongoing leakage.