New laxative therapies: Lubiprostone is a chloride channel stimulator that increases the secretion of water into the intestine (secretogogue
Kids actually have relatively well-maintained beta-cell function, so when you give them a secretogogue
, they're able to produce large amounts of insulin, leading to substantial hypoglycemia.
The new insulin secretogogue
repaglinide can be used in patients with impaired renal function.
Magnoflorine showed significant insulin secretogogue
activity at 10 and 20 mg/kg dose levels too.
These drugs are divided into several groups according to their mechanisms as secretogogues
(sulfonylureas and meglitinides), insulin sensitizers (biguanides and thiazolidinediones), and [alpha]-glucosidase inhibitors (miglitol and acarbose) (7).
Treatment can be provided to individuals with impaired salivary function by use of parasympathomometic secretogogues
, which are drugs that increase salivary output by working on the acinar cells of the salivary glands.
When these regulatory mechanisms malfunction, acid and pepsin autodiagest the mucosa resulting in the ulceration of oesophagus, stomach and duodenum.14 Histamine, acetylcholine or Carbachol are potent secretogogues
for the parietal cells of gastric mucosa leading to the production of HCl.15 Acetylcholine and gastrin act through calcium ions.
Repaglinide: These belong to the class of non-sulfonylurea insulin secretogogues
. They have several desirable properties including a rapid onset and short duration of action, and metabolism and excretion by non-renal routes.
Systemic drugs, termed secretogogues
, may be prescribed.
(8) DRY EYE SEVERITY LEVELS 1 * Education and Environmental/ Dietary modifications * Elimination of offending systemic medications * Artificial tear substitutes, gels/ ointments * Eye lid therapy 2 If Level 1 treatments are inadequate, add: * Anti-inflammatories * Tetracyclines (for meibomitis, acne rosacea) * Punctal plugs * Secretogogues
* Moisture chamber spectacles 3 If Level 2 treatments are inadequate, add: * Autologous Serum * Contact lenses * Permanent punctal occlusion 4 * If Level 3 treatments are inadequate, add: * Systemic anti-inflammatory agents * Surgery (lid surgery, tarsorrhaphy; mucus membrane, salivary gland, amniotic membrane transplantation)