Because of the profuse secretory diarrhea
experienced by some patients, it has been hypothesized that Cryptosporidium produces an enterotoxin (Fayer, 2004).
If you subscribe to the idea that diarrhea helps rid the body of toxins, be reminded that secretory diarrhea
is exploited by the organism to spread the infestation to as many humans as possible.
Vanda stated that CFTR activators and inhibitors may have broad applicability in addressing a number of high unmet medical needs, including chronic dry eye, constipation, polycystic kidney disease, cholestasis and secretory diarrhea
Watery diarrhea, hypokalemia and achlorhydria syndrome is a rare cause of chronic secretory diarrhea
arising from a vasoactive intestinal peptide releasing tumor.
Diarrhea and Enteric Dysfunction: We seek new ideas for tools, approaches, and models to support preclinical development of new agents for Acute Secretory Diarrhea
and Environmental Enteric Dysfunction.
cholerae O1 and O139 serogroups produce cholera toxin (CT), a critical virulence factor and express toxin coregulated pilus (TCP), which are responsible for secretory diarrhea
and intestinal colonization, respectively.
4,12) It causes severe and intractable secretory diarrhea
(150-300 ml/kg/day) that usually starts shortly after birth and persists despite total bowel rest, (1,2,4,8,13) resulting in severe dehydration and profound metabolic acidosis.
diff secrete potent enterotoxins which damage the colonic mucosa and cause a secretory diarrhea
More for-profit pharmaceutical companies, such as Roche and Novartis, are entering cooperative relationships with the Institute for OneWorld Health (for example, the institute recently signed a collaboration agreement with Novartis to discover and develop a novel therapy for secretory diarrhea
, a deadly disease that kills more than 1.
In adults, the most common etiologies were secretory diarrhea
(idiopathic, laxative abuse, irritable bowel syndrome, diabetes mellitus, and fecal incontinence), malabsorption (pancreatic disease, noninflammatory short bowel syndrome, postgastrectomy, hyperthyroidism, and cholestasis), microscopic colitis, inflammatory bowel disease, celiac sprue, and radiation colitis.